INT253762

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.29
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Apex1, Hmgb1) nucleus (Apex1, Hmgb1) cytoplasm (Apex1, Hmgb1)
nucleolus (Apex1, Hmgb1) nucleoplasm (Apex1) mitochondrion (Apex1)
Anatomy Link Frequency
neutrophils 1
Apex1 (Mus musculus)
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 27 90.52 High High
Inflammatory mediators 15 80.08 Quite High
Glutamate 1 72.72 Quite High
excitatory amino acid 1 71.48 Quite High
cytokine 23 69.44 Quite High
Inflammation 36 69.04 Quite High
antagonist 2 39.48 Quite Low
chemokine 5 34.84 Quite Low
vagus nerve 6 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 11 100.00 Very High Very High Very High
INFLAMMATION 83 90.16 High High
Injury 14 80.00 Quite High
Fever 3 73.76 Quite High
Disease 14 55.52 Quite High
Infection 18 47.52 Quite Low
Sepsis 99 42.24 Quite Low
Adhesions 1 35.36 Quite Low
Cancer 5 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, a recent study indicated that HMGB1
           could interact with phosphatidylserine on the cell surface of apoptotic neutrophils, and
           consequently inhibit phagocytotic elimination of apoptotic neutrophils by macrophages
           (Ref. 93). 
Ref Binding (interact) of HMGB1 in neutrophils associated with apoptosis
1) Confidence 0.09 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.29 Pain Relevance 0.32

General Comments

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