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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.27
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Apex1, Hmgb1) nucleus (Apex1, Hmgb1) cytoplasm (Apex1, Hmgb1)
nucleolus (Apex1, Hmgb1) nucleoplasm (Apex1) mitochondrion (Apex1)
Apex1 (Mus musculus)
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 23 100.00 Very High Very High Very High
Inflammation 36 82.32 Quite High
Inflammatory response 27 70.08 Quite High
Inflammatory mediators 15 65.24 Quite High
Glutamate 1 18.28 Low Low
excitatory amino acid 1 17.04 Low Low
vagus nerve 6 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 99 99.88 Very High Very High Very High
Disease 14 82.68 Quite High
INFLAMMATION 83 82.32 Quite High
Injury 14 81.44 Quite High
Infection 18 81.00 Quite High
Apoptosis 11 74.12 Quite High
Cancer 5 38.64 Quite Low
Necrosis 4 38.08 Quite Low
Fever 3 19.32 Low Low
Adult Respiratory Distress Syndrome 4 15.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This late appearance of circulating HMGB1 precedes and parallels the onset of animal
           lethality from endotoxaemia or sepsis, and distinguishes HMGB1 from TNF and other early
           proinflammatory cytokines (Ref. 96) (Fig. 3). 
Ref Positive_regulation (distinguishes) of HMGB1 associated with sepsis and cytokine
1) Confidence 0.09 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.27 Pain Relevance 0.24

General Comments

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