INT253767

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.78
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hmgb1, Tlr9) endosome (Tlr9) cell morphogenesis (Hmgb1)
endoplasmic reticulum (Tlr9) intracellular (Tlr9) DNA binding (Hmgb1)
Hmgb1 (Mus musculus)
Tlr9 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 29 99.96 Very High Very High Very High
Inflammation 60 94.84 High High
ischemia 10 90.44 High High
chemokine 11 87.12 High High
cytokine 40 81.84 Quite High
fibrosis 6 56.20 Quite High
antagonist 3 49.84 Quite Low
Inflammatory stimuli 2 29.32 Quite Low
Inflammatory mediators 16 5.00 Very Low Very Low Very Low
vagus nerve 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 109 99.76 Very High Very High Very High
Cv Unclassified Under Development 11 90.44 High High
Injury 61 84.88 Quite High
Infection 25 84.48 Quite High
Apoptosis 21 79.88 Quite High
Death 5 79.20 Quite High
Necrosis 5 78.28 Quite High
Sepsis 101 76.68 Quite High
Cancer 5 73.60 Quite High
Dengue 1 61.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, extracellular HMGB1 can bind to biologically
           active microbial CpG-DNA, and facilitate its innate recognition by the intracellular
           TLR9 receptor, thereby augmenting CpG-DNA-induced inflammatory responses (Refs 52, 71).


HMGB1 Binding (recognition) of TLR9 receptor associated with inflammatory response
1) Confidence 0.12 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.65 Pain Relevance 0.22
Released in the extracellular compartment during acute inflammatory responses, HMGB1 also interact with TLR2 [21] and TLR9 [22].
HMGB1 Binding (interact) of TLR9 associated with inflammatory response
2) Confidence 0.11 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.13 Pain Relevance 0.31

General Comments

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