INT253770

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.71
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Hmgb1, Apex1) nucleus (Hmgb1, Apex1) cytoplasm (Hmgb1, Apex1)
nucleolus (Hmgb1, Apex1) nucleoplasm (Apex1) mitochondrion (Apex1)
Anatomy Link Frequency
brain 2
Hmgb1 (Mus musculus)
Apex1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 36 100.00 Very High Very High Very High
cytokine 23 100.00 Very High Very High Very High
excitatory amino acid 1 99.04 Very High Very High Very High
Glutamate 1 97.28 Very High Very High Very High
antagonist 2 72.24 Quite High
chemokine 5 67.60 Quite High
Inflammatory response 27 59.92 Quite High
Inflammatory mediators 15 5.00 Very Low Very Low Very Low
vagus nerve 6 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 83 100.00 Very High Very High Very High
Fever 3 96.08 Very High Very High Very High
Injury 14 94.00 High High
Adhesions 1 68.12 Quite High
Apoptosis 11 54.64 Quite High
Infection 18 25.12 Quite Low
Cancer 5 14.24 Low Low
Sepsis 99 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the brain, exogenous HMGB1 induces the release of pro-inflammatory cytokines (Ref.
             86) and excitatory amino acids (such as
           glutamate) (Ref. 87), induces fever (Ref. 88), and exacerbates cerebral ischaemic injury
           (Ref. 89). 
HMGB1 Positive_regulation (induces) of Localization (release) of Ref in brain associated with glutamate, inflammation, injury, fever, excitatory amino acid and cytokine
1) Confidence 0.08 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.71 Pain Relevance 0.49

General Comments

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