INT253772

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.95
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (THBD, Hmgb1) cell morphogenesis (Hmgb1) DNA binding (Hmgb1)
embryo development (THBD) cytoplasm (Hmgb1) extracellular region (Hmgb1)
THBD (Homo sapiens)
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 72 98.12 Very High Very High Very High
Inflammatory response 54 83.36 Quite High
Inflammatory mediators 30 51.72 Quite High
cytokine 46 45.44 Quite Low
rheumatoid arthritis 6 43.76 Quite Low
Etanercept 2 34.04 Quite Low
Infliximab 2 30.96 Quite Low
vagus nerve 12 5.00 Very Low Very Low Very Low
cINOD 10 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 166 98.12 Very High Very High Very High
Sepsis 198 86.88 High High
Disease 28 67.40 Quite High
Coagulation Disorder 6 63.12 Quite High
Thrombocytopenia 2 51.36 Quite High
Rheumatoid Arthritis 6 43.76 Quite Low
Adult Respiratory Distress Syndrome 8 42.08 Quite Low
Infection 36 9.44 Low Low
Autoimmune Disease 2 8.48 Low Low
Injury 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, many exogenous bacterial products (such as endotoxin or CpG-DNA) (Refs 52, 71, 72) or endogenous proteins (such as human
       thrombomodulin, IgG1 or IL-1) (Refs 115, 150) may physically interact with HMGB1 to form
       various complexes. 
thrombomodulin Binding (interact) of HMGB1
1) Confidence 0.05 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.27 Pain Relevance 0
Interestingly, human soluble thrombomodulin (ART-123)
           can physically bind to HMGB1 protein, thereby inhibiting an HMGB1-mediated inflammatory
           response. 
thrombomodulin Binding (bind) of HMGB1 associated with inflammation
2) Confidence 0.05 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.68 Pain Relevance 0.12

General Comments

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