INT253775

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.69
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (THBD, Hmgb1) cell morphogenesis (Hmgb1) DNA binding (Hmgb1)
embryo development (THBD) cytoplasm (Hmgb1) extracellular region (Hmgb1)
THBD (Homo sapiens)
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 36 99.24 Very High Very High Very High
Inflammatory response 27 85.60 High High
Inflammatory mediators 15 51.72 Quite High
cytokine 23 5.00 Very Low Very Low Very Low
vagus nerve 6 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 83 99.24 Very High Very High Very High
Sepsis 99 77.80 Quite High
Coagulation Disorder 3 65.36 Quite High
Thrombocytopenia 1 53.60 Quite High
Adult Respiratory Distress Syndrome 4 44.32 Quite Low
Disease 14 14.24 Low Low
Infection 18 11.68 Low Low
Autoimmune Disease 1 10.72 Low Low
Injury 14 5.00 Very Low Very Low Very Low
Apoptosis 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, human soluble thrombomodulin (ART-123)
           can physically bind to HMGB1 protein, thereby inhibiting an HMGB1-mediated inflammatory
           response. 
Negative_regulation (inhibiting) of thrombomodulin Binding (bind) of HMGB1 associated with inflammation
1) Confidence 0.06 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.69 Pain Relevance 0.12

General Comments

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