INT253776

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (THBD, F2) peptidase activity (F2) extracellular region (F2)
plasma membrane (THBD) embryo development (THBD)
Anatomy Link Frequency
plasma 1
THBD (Homo sapiens)
F2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 72 86.80 High High
Inflammatory response 54 76.36 Quite High
Inflammatory mediators 30 56.00 Quite High
dexamethasone 6 38.20 Quite Low
cINOD 10 30.76 Quite Low
cytokine 46 22.28 Low Low
vagus nerve 12 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coagulation Disorder 6 90.36 High High
INFLAMMATION 166 86.80 High High
Sepsis 198 82.08 Quite High
Disseminated Intravascular Coagulation 2 78.40 Quite High
Adrenal Insufficiency 2 49.92 Quite Low
Thrombocytopenia 2 41.92 Quite Low
Body Weight 2 39.20 Quite Low
Adult Respiratory Distress Syndrome 8 32.64 Quite Low
Infection 36 5.00 Very Low Very Low Very Low
Injury 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As mentioned above, another anticoagulant molecule, thrombomodulin, can interact with
           thrombin to activate protein C. 
thrombomodulin Binding (interact) of thrombin
1) Confidence 0.00 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.61 Pain Relevance 0.11
Following engagement of thrombin to thrombomodulin, the ability of
         thrombin to catalyse procoagulant reactions is inhibited, but its ability to activate a
         plasma anticoagulant, activated protein C, is enhanced >1000-fold, which results in
         inactivation of blood clotting factors. 
thrombomodulin Binding (engagement) of thrombin in plasma associated with coagulation disorder
2) Confidence 0.00 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.54 Pain Relevance 0.07

General Comments

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