INT25381

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 1982
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 62
Total Number 62
Disease Relevance 47.48
Pain Relevance 9.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
T cells 5
macrophage 4
lung 2
granulocyte 2
leukocytes 2
Csf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 747 100.00 Very High Very High Very High
cytokine 596 100.00 Very High Very High Very High
Multiple sclerosis 170 100.00 Very High Very High Very High
chemokine 152 100.00 Very High Very High Very High
tail-flick 2 99.30 Very High Very High Very High
antagonist 56 98.92 Very High Very High Very High
dexamethasone 200 98.84 Very High Very High Very High
Morphine 2 98.54 Very High Very High Very High
Antinociceptive 2 98.14 Very High Very High Very High
Spinal cord 24 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 815 100.00 Very High Very High Very High
Demyelinating Disease 191 100.00 Very High Very High Very High
Lymphatic System Cancer 71 99.96 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 507 99.84 Very High Very High Very High
Lewis Lung Carcinoma 4 99.74 Very High Very High Very High
Cancer 2105 99.70 Very High Very High Very High
Cyst 2 99.68 Very High Very High Very High
Apoptosis 528 99.58 Very High Very High Very High
Nicotine Addiction 166 99.46 Very High Very High Very High
Chlamydia Infection 201 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we tested whether other agents known to increase cAMP, such as forskolin and cholera toxin, could act in conjunction with IL-2 to induce GM-CSF secretion.
Localization (secretion) of GM-CSF associated with vibrio infection
1) Confidence 0.76 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2521509 Disease Relevance 0.10 Pain Relevance 0.10
Prostaglandin E2-dependent induction of granulocyte-macrophage colony-stimulating factor secretion by cloned murine helper T cells.
Localization (secretion) of granulocyte-macrophage colony-stimulating factor in macrophage
2) Confidence 0.76 Published 1989 Journal J. Immunol. Section Title Doc Link 2521509 Disease Relevance 0.06 Pain Relevance 0.04
Overall these data indicate that the requirements for activation of GM-CSF secretion vary among individual T cells.
Localization (secretion) of GM-CSF in T cells
3) Confidence 0.76 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2521509 Disease Relevance 0.09 Pain Relevance 0.11
Pre clinical and early clinical studies and the rationale for GM-CSF as an adjunctive treatment in HIV infection
Localization (rationale) of GM-CSF associated with acquired immune deficiency syndrome or hiv infection and infection
4) Confidence 0.74 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 0.99 Pain Relevance 0.07
In the largest double blind, randomized controlled trial on GM-CSF use in HIV infected individuals published to date, 309 subjects stratified according to viral load (?
Localization (use) of GM-CSF associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.74 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 0.39 Pain Relevance 0
Finally, a Swiss study evaluated the use of GM-CSF 300 ?
Localization (use) of GM-CSF
6) Confidence 0.74 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 0.16 Pain Relevance 0
In summary, our data suggest that the persistently increased secretion of the inflammatory mediator GM-CSF by resident inflammatory cells but also by SMC may be the trigger of aortic wall structural deterioration.
Localization (secretion) of GM-CSF associated with inflammation
7) Confidence 0.72 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2933604 Disease Relevance 0.34 Pain Relevance 0.17
Despite this, there were some important benefits to the use of GM-CSF on other clinical events.
Localization (use) of GM-CSF
8) Confidence 0.70 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 1.69 Pain Relevance 0.06
However, attempts to have consistently high GM-CSF secretion at the vaccine site (>2000 ng/106 cells/24 h) induced by a GM-CSF-producing bystander cell line mixed to the autologous NSCLC cells failed to show association between either tumor cell dose or GM-CSF dose and survival [28].
Localization (secretion) of GM-CSF associated with cancer and non-small-cell lung cancer
9) Confidence 0.64 Published 2007 Journal J Transl Med Section Body Doc Link PMC2020458 Disease Relevance 0.94 Pain Relevance 0
While the reason for the failure remains unknown, the significant increase in GM-CSF secretion by the "bystander" GVAX (25 fold higher than the autologous vaccine) may have also had a negative effect.
Localization (secretion) of GM-CSF
10) Confidence 0.64 Published 2007 Journal J Transl Med Section Body Doc Link PMC2020458 Disease Relevance 0.57 Pain Relevance 0
In this context, Serafini and coworkers have reported, that tumor vaccines that secrete high levels of GM-CSF induce myeloid suppressor cells that, in turn, inhibit anti-tumor immunity [29].
Localization (secrete) of GM-CSF in myeloid suppressor cells associated with cancer
11) Confidence 0.64 Published 2007 Journal J Transl Med Section Body Doc Link PMC2020458 Disease Relevance 0.52 Pain Relevance 0
Secretion of GM-CSF by genetically-modified tumor cells stimulates cytokine release at the vaccine site to activate antigen-presenting cells, which prime CD4+ and CD8+ T cells to recognize circulating tumor-associated antigens, thereby inducing a tumor-specific cellular immune response.
Localization (Secretion) of GM-CSF in T cells associated with cancer and cytokine
12) Confidence 0.64 Published 2007 Journal J Transl Med Section Body Doc Link PMC2020458 Disease Relevance 2.03 Pain Relevance 0.17
Vaccination with irradiated NSCLC cells genetically modified to secrete GM-CSF has demonstrated safety and significant clinical efficacy [2,3].
Localization (secrete) of GM-CSF associated with non-small-cell lung cancer
13) Confidence 0.64 Published 2007 Journal J Transl Med Section Body Doc Link PMC2020458 Disease Relevance 1.17 Pain Relevance 0
Upon significant disruption of neuronal architecture, tau protein could be released into CSF [60].
Localization (released) of CSF in neuronal
14) Confidence 0.63 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 0.82 Pain Relevance 0
Our data suggest that the persistently increased secretion of the inflammatory mediator GM-CSF by resident inflammatory cells but also by SMC may be the trigger of aortic wall structural deterioration.



Localization (secretion) of GM-CSF associated with inflammation
15) Confidence 0.63 Published 2010 Journal J Cardiothorac Surg Section Abstract Doc Link PMC2933604 Disease Relevance 0.85 Pain Relevance 0.21
The results presented herein support the hypothesis that the antinociceptive action of morphine in mice as measured by the tail-flick procedure can be mediated via the release of endogenous compound(s) from brain into CSF which are transported to lower sections of the spinal cord where they inhibit the tail-flick response.
Localization (release) of CSF in tail associated with tail-flick, antinociceptive, spinal cord and morphine
16) Confidence 0.61 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6281413 Disease Relevance 0 Pain Relevance 0.87
LLC is known to release CSF.
Localization (release) of CSF associated with lewis lung carcinoma
17) Confidence 0.60 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9629267 Disease Relevance 0.79 Pain Relevance 0.67
-secretase occurs via nonamyloidogenic pathway, and a reduced CSF level of sAPP?
Localization (occurs) of CSF
18) Confidence 0.59 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.07 Pain Relevance 0
Colony stimulating factors GM-CSF (Csf2) and G-CSF (Csf3) produced and secreted by 4T1 cells stimulate hematopoiesis along the myeloid lineages and are likely to be responsible for the high levels of hematopoiesis and circulating leukocytes observed when tumors from 4T1 cells are established in vivo [17].
Localization (secreted) of Csf2 in leukocytes associated with hematological disease and cancer
19) Confidence 0.57 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.82 Pain Relevance 0.03
Early-phase human clinical trials of GM-CSF-secreting autologous tumor cells in lung cancer have demonstrated the relative safety of this treatment approach as well as the induction of tumor-specific immune responses and evidence of anti-tumor activity [2,3].
Localization (-) of GM-CSF in lung associated with lung cancer and cancer
20) Confidence 0.56 Published 2007 Journal J Transl Med Section Body Doc Link PMC2020458 Disease Relevance 1.53 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox