INT253813

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Anatomy Link Frequency
ganglion 2
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 108 99.84 Very High Very High Very High
Cholecystokinin 96 99.08 Very High Very High Very High
medulla 27 90.00 High High
Locus ceruleus 1 80.80 Quite High
cytokine 16 75.48 Quite High
antagonist 16 74.56 Quite High
Kinase C 1 74.00 Quite High
analgesia 2 72.76 Quite High
Inflammatory response 1 59.92 Quite High
cocaine 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Weight Gain 3 100.00 Very High Very High Very High
Osteoarthritis 86 99.84 Very High Very High Very High
Ganglion Cysts 1 97.52 Very High Very High Very High
Knee Osteoarthritis 34 83.12 Quite High
Anxiety Disorder 16 71.44 Quite High
Obesity 76 60.96 Quite High
INFLAMMATION 21 59.52 Quite High
Body Weight 5 57.56 Quite High
Aids-related Complex 5 52.48 Quite High
Hyperalgesia 7 44.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, recent studies have shown that mice deficient in leptin or the leptin receptor undergo extreme weight gain but exhibit no changes in osteoarthritis [76].
Neg (no) Regulation (changes) of Negative_regulation (deficient) of leptin associated with weight gain and osteoarthritis
1) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.73 Pain Relevance 0.31
Interestingly, a lowered leptin level after 48- hour food deprivation affected expression neither of CCK-A receptor [23] nor CART in nodose ganglion neurons [24].
Neg (neither) Regulation (affected) of Negative_regulation (deprivation) of leptin in ganglion associated with ganglion cysts and cholecystokinin
2) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.28 Pain Relevance 0.81

General Comments

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