INT25382

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Context Info
Confidence 0.37
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 11.69
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
T cells 3
lungs 1
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 81 99.96 Very High Very High Very High
rheumatoid arthritis 80 99.84 Very High Very High Very High
Inflammation 112 96.76 Very High Very High Very High
corticosteroid 2 96.56 Very High Very High Very High
addiction 2 96.08 Very High Very High Very High
Bile 2 94.60 High High
anesthesia 3 92.80 High High
imagery 8 87.44 High High
Opioid 2 84.72 Quite High
Arthritis 36 65.04 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 83 99.84 Very High Very High Very High
Immunotherapy Of Cancer 26 99.80 Very High Very High Very High
Vibrio Infection 2 99.58 Very High Very High Very High
Skin Cancer 20 99.04 Very High Very High Very High
Cancer 348 98.68 Very High Very High Very High
Hematological Disease 2 98.48 Very High Very High Very High
Stress 52 97.28 Very High Very High Very High
Renal Cancer 6 97.04 Very High Very High Very High
Toxicity 16 96.92 Very High Very High Very High
INFLAMMATION 126 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Combining preimmunization with FECA and IL-2 and resection of local melanoma tumors decreased the mortality and the number of mice with local recurrence and metastatic melanoma tumors to the lungs.
IL-2 Binding (preimmunization) of in lungs associated with cancer, skin cancer and recurrence
1) Confidence 0.37 Published 1993 Journal J Surg Oncol Section Abstract Doc Link 8441268 Disease Relevance 1.02 Pain Relevance 0.09
Moreover, melatonin protects mice injected with encephalitogenic viruses, synergizes with interleukin-2 (IL-2) in cancer immunotherapy and rescues hematopoiesis from cancer chemotherapy toxicity.
interleukin-2 Binding (synergizes) of associated with toxicity, hematological disease, cancer and immunotherapy of cancer
2) Confidence 0.36 Published 1996 Journal J. Pineal Res. Section Abstract Doc Link 8797184 Disease Relevance 1.07 Pain Relevance 0.17
Moreover, melatonin protects mice injected with encephalitogenic viruses, synergizes with interleukin-2 (IL-2) in cancer immunotherapy and rescues hematopoiesis from cancer chemotherapy toxicity.
IL-2 Binding (synergizes) of associated with toxicity, hematological disease, cancer and immunotherapy of cancer
3) Confidence 0.36 Published 1996 Journal J. Pineal Res. Section Abstract Doc Link 8797184 Disease Relevance 1.07 Pain Relevance 0.17
Most interesting, however, was the finding that PGE2 and PGE1 could act synergistically with IL-2 for the induction of GM-CSF in some TH1 clones.
IL-2 Binding (act) of
4) Confidence 0.30 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2521509 Disease Relevance 0.06 Pain Relevance 0.05
Therefore, we tested whether other agents known to increase cAMP, such as forskolin and cholera toxin, could act in conjunction with IL-2 to induce GM-CSF secretion.
IL-2 Binding (conjunction) of associated with vibrio infection
5) Confidence 0.30 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2521509 Disease Relevance 0.10 Pain Relevance 0.10
However, this mAb can potentially form an immune complex with IL-2 and induce CD8+ T cell proliferation [39].
IL-2 Binding (complex) of in T cell
6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.47 Pain Relevance 0.04
A similar "broad activation" principle serves as a rationale for systemic interleukin-2 (IL-2) administration, which is currently used as anti-cancer immunotherapy in renal cell cancer and metastatic melanoma [25].
IL-2 Binding (rationale) of associated with renal cancer, skin cancer and immunotherapy of cancer
7) Confidence 0.18 Published 2007 Journal Infect Agent Cancer Section Body Doc Link PMC2211456 Disease Relevance 1.69 Pain Relevance 0
A similar "broad activation" principle serves as a rationale for systemic interleukin-2 (IL-2) administration, which is currently used as anti-cancer immunotherapy in renal cell cancer and metastatic melanoma [25].
interleukin-2 Binding (rationale) of associated with renal cancer, skin cancer and immunotherapy of cancer
8) Confidence 0.18 Published 2007 Journal Infect Agent Cancer Section Body Doc Link PMC2211456 Disease Relevance 1.69 Pain Relevance 0
To investigate whether IL-2 recovers from the decrease of Treg differentiation caused by 1,25(OH)2D3, we added recombinant IL-2 (rIL-2) on the culture medium of CD4+ T cells in the presence of TGF-?
IL-2 Binding (recombinant) of in T cells
9) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0 Pain Relevance 0
Briefly, three bead populations with distinct fluorescence intensities and coated with capture antibodies specific for IL-2, IFN-?
IL-2 Binding (specific) of
10) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811739 Disease Relevance 0.12 Pain Relevance 0.11
, IL-2) and Th2 (IL-5 and IL-6) associated cytokines.
IL-2 Binding (associated) of associated with cytokine
11) Confidence 0.10 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2270279 Disease Relevance 0.24 Pain Relevance 0.30
in murine T cells,25 using a combination of IL-2, IL-6, and TNF-?
IL-2 Binding (combination) of in T cells
12) Confidence 0.05 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.10 Pain Relevance 0.27
DNA-lipid complex encoding the interleukin 2 (IL-2) gene (Leuvectin; Vical, San Diego, Calif) administered intraprostatically into the hypo-echogenic tumour
interleukin 2 Binding (complex) of associated with cancer
13) Confidence 0.05 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.83 Pain Relevance 0.09
DNA-lipid complex encoding the interleukin 2 (IL-2) gene (Leuvectin; Vical, San Diego, Calif) administered intraprostatically into the hypo-echogenic tumour
IL-2 Binding (complex) of associated with cancer
14) Confidence 0.05 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.83 Pain Relevance 0.09
KIR2DL1, 2, and 3 by treatment with IL-2 was weaker in RA
IL-2 Binding (treatment) of associated with rheumatoid arthritis
15) Confidence 0.02 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 1.20 Pain Relevance 0.42
KIR2DL1, 2, and 3 by treatment with IL-2 was weaker in RA
IL-2 Binding (weaker) of associated with rheumatoid arthritis
16) Confidence 0.02 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 1.20 Pain Relevance 0.42

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