INT25383

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Context Info
Confidence 0.76
First Reported 1982
Last Reported 2011
Negated 13
Speculated 1
Reported most in Body
Documents 222
Total Number 223
Disease Relevance 152.93
Pain Relevance 43.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
macrophage 16
CSF 10
spinal 6
brain 6
neutrophil 5
Csf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2530 100.00 Very High Very High Very High
cytokine 2197 100.00 Very High Very High Very High
chemokine 908 100.00 Very High Very High Very High
gABA 93 99.96 Very High Very High Very High
rheumatoid arthritis 973 99.84 Very High Very High Very High
Morphine 30 99.84 Very High Very High Very High
agonist 192 99.72 Very High Very High Very High
Multiple sclerosis 700 99.70 Very High Very High Very High
Osteoarthritis 146 99.56 Very High Very High Very High
Pain 150 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 2905 100.00 Very High Very High Very High
INFLAMMATION 2658 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1753 100.00 Very High Very High Very High
Targeted Disruption 536 100.00 Very High Very High Very High
Adhesions 214 100.00 Very High Very High Very High
Leukocytosis 11 100.00 Very High Very High Very High
Pulmonary Alveolar Proteinosis 390 99.92 Very High Very High Very High
Meningioma 91 99.92 Very High Very High Very High
Solid Tumor 15 99.92 Very High Very High Very High
Pressure And Volume Under Development 261 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, GM-CSF knockout mice improved bacterial clearance after expression of GM-CSF in the respiratory epithelium (16).
Gene_expression (expression) of GM-CSF in epithelium associated with targeted disruption
1) Confidence 0.76 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526424 Disease Relevance 0.97 Pain Relevance 0.37
DISC-HSV-2 has been shown to be an efficient vector for cytokine gene delivery into tumour cells, and that the expression of mGM-CSF or hIL-2 enhances the immunogenicity of whole-cell vaccines [108, 109].
Gene_expression (expression) of GM-CSF associated with cold sores, cancer and cytokine
2) Confidence 0.75 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.31 Pain Relevance 0.05
Dependence on PGE2 for this response was not found in all clones, as some TH1 cells could produce GM-CSF after IL-2 alone, and some cells did not produce GM-CSF even in the presence of PGE2 and IL-2.
Gene_expression (produce) of GM-CSF associated with addiction
3) Confidence 0.73 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2521509 Disease Relevance 0.07 Pain Relevance 0.05
Dependence on PGE2 for this response was not found in all clones, as some TH1 cells could produce GM-CSF after IL-2 alone, and some cells did not produce GM-CSF even in the presence of PGE2 and IL-2.
Neg (not) Gene_expression (produce) of GM-CSF associated with addiction
4) Confidence 0.73 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2521509 Disease Relevance 0.08 Pain Relevance 0.05
Here, we report the effects of morphine on purified approximately 12-kDa component of Leishmania donovani amastigote antigen (LDAA-12)-induced colony-stimulating factor (CSF) production by mouse peritoneal macrophages (PMs) in vitro.
Gene_expression (production) of CSF in PMs associated with morphine
5) Confidence 0.69 Published 2005 Journal Microbes Infect. Section Abstract Doc Link 15716055 Disease Relevance 0.18 Pain Relevance 0.49
Low concentrations (1 x 10(-9) and 1 x 10(-11) M) of morphine significantly (P < 0.05) augmented the production of CSFs, whereas high concentrations (1 x 10(-3) and 1 x 10(-5) M) inhibited CSF production.
Gene_expression (production) of CSF associated with morphine
6) Confidence 0.69 Published 2005 Journal Microbes Infect. Section Abstract Doc Link 15716055 Disease Relevance 0.16 Pain Relevance 0.68
Impact of GM-CSF on clinical outcomes
Gene_expression (Impact) of GM-CSF
7) Confidence 0.67 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 0.54 Pain Relevance 0.09
The first randomized controlled trial on the use of GM-CSF in non-neutropenic HIV-1 infected subjects, published in 1999, did not show any significant effect of GM-CSF on plasma HIV RNA levels [15].
Gene_expression (effect) of GM-CSF in plasma associated with acquired immune deficiency syndrome or hiv infection
8) Confidence 0.67 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 0.95 Pain Relevance 0
As such, there were fewer changes in ARVD regimens in the GM-CSF group (19%) than in the placebo group (38%) for the lower viral load stratum (p = 0.03).
Gene_expression (group) of GM-CSF
9) Confidence 0.67 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 0.35 Pain Relevance 0
Impact of GM-CSF use in HIV infected individuals
Gene_expression (use) of GM-CSF associated with acquired immune deficiency syndrome or hiv infection
10) Confidence 0.67 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 1.03 Pain Relevance 0
As other randomized control trials show trends towards higher CD4+ T cell counts in the GM-CSF group, and statistically significant difference in various sub-analysis, it is possible that an appropriately conducted meta-analysis would clarify the impact of GM-CSF on CD4+ T cell counts.
Gene_expression (group) of GM-CSF in T cell
11) Confidence 0.67 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 0.09 Pain Relevance 0
Mean HIV RNA levels declined in the GM-CSF group throughout the 6 months of the study.
Gene_expression (group) of GM-CSF associated with acquired immune deficiency syndrome or hiv infection
12) Confidence 0.67 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 0.59 Pain Relevance 0
g GM-CSF daily for 1 week then 150 ?
Gene_expression (daily) of GM-CSF
13) Confidence 0.67 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 0.28 Pain Relevance 0
The mean HIV RNA plasma levels at baseline were 93000 copies/ml in the placebo group and 155000 copies/ml in the GM-CSF group (p = 0.21).
Gene_expression (group) of GM-CSF in plasma associated with acquired immune deficiency syndrome or hiv infection
14) Confidence 0.67 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 0.65 Pain Relevance 0
When incremental doses of GM-CSF (0, 1, 10, or 100 ng/mL) were added to high doses of LPS (100 ng/mL), the expression of TNF-?
Gene_expression (doses) of GM-CSF
15) Confidence 0.66 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526424 Disease Relevance 0.26 Pain Relevance 0.35
increased; this was dependent on the dose of GM-CSF used (Fig. 5).
Gene_expression (used) of GM-CSF
16) Confidence 0.66 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526424 Disease Relevance 0.67 Pain Relevance 0.31
Stimulation of bone marrow-derived mouse neutrophils with LPS and/or GM-CSF
Gene_expression (/) of GM-CSF in neutrophils
17) Confidence 0.66 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526424 Disease Relevance 0 Pain Relevance 0.03
Of note, when GM-CSF was administered with high doses of LPS (100 ng/mL), the expression of three cytokines (TNF-?
Gene_expression (administered) of GM-CSF associated with cytokine
18) Confidence 0.66 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526424 Disease Relevance 0.76 Pain Relevance 0.36
Furthermore, a threshold effect for vaccine GM-CSF production on survival was noted in these trials, with longer survival seen in patients receiving vaccines secreting >40 ng GM-CSF/106 cells/24 h [3].
Gene_expression (production) of GM-CSF
19) Confidence 0.62 Published 2007 Journal J Transl Med Section Body Doc Link PMC2020458 Disease Relevance 1.09 Pain Relevance 0
A combined analysis of CSF-A?
Gene_expression (analysis) of CSF
20) Confidence 0.61 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.64 Pain Relevance 0.16

General Comments

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