INT25385

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Context Info
Confidence 0.45
First Reported 1989
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 9.53
Pain Relevance 6.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
lymphocytes 4
T cells 4
thymus 3
plasma 2
B cells 2
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 251 100.00 Very High Very High Very High
rheumatoid arthritis 130 99.62 Very High Very High Very High
Opioid 5 99.24 Very High Very High Very High
agonist 8 99.20 Very High Very High Very High
Morphine 28 98.82 Very High Very High Very High
addiction 1 98.10 Very High Very High Very High
cocaine 12 97.00 Very High Very High Very High
Dynorphin 1 96.08 Very High Very High Very High
Inflammation 171 92.88 High High
opiate 8 91.60 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 187 99.62 Very High Very High Very High
Autoimmune Disease 3 99.36 Very High Very High Very High
Pulmonary Disease 60 97.84 Very High Very High Very High
Cancer 42 97.04 Very High Very High Very High
Mycobacterial Infection 5 95.68 Very High Very High Very High
Infection 85 95.64 Very High Very High Very High
Disease 99 94.56 High High
Synovitis 21 94.56 High High
Targeted Disruption 9 93.64 High High
INFLAMMATION 186 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, arachidonic acid caused a concentration-dependent inhibition of interleukin-2 secretion (IC(50) = 10.3 microM), which was similar to that of structurally related anandamide (IC(50) = 11.4 microM).
Positive_regulation (caused) of Localization (secretion) of interleukin-2
1) Confidence 0.45 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15284281 Disease Relevance 0.13 Pain Relevance 0.15
Dependence on PGE2 for this response was not found in all clones, as some TH1 cells could produce GM-CSF after IL-2 alone, and some cells did not produce GM-CSF even in the presence of PGE2 and IL-2.
Positive_regulation (after) of Localization (presence) of IL-2 associated with addiction
2) Confidence 0.41 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2521509 Disease Relevance 0.08 Pain Relevance 0.05
Deltorphin showed a biphasic effect: 10(-11) M enhanced IL-2 secretion, whereas higher concentrations (10(-9)-10(-7) M) were inhibitory.
Positive_regulation (enhanced) of Localization (secretion) of IL-2
3) Confidence 0.40 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791081 Disease Relevance 0 Pain Relevance 0.07
Activation of melatonin receptors enhances the release of Th cell cytokines, such as gamma-interferon and interleukin-2, as well as novel opioid cytokines which cross-react immunologically with both interleukin-4 and dynorphin B.
Positive_regulation (enhances) of Localization (release) of interleukin-2 associated with dynorphin, opioid and cytokine
4) Confidence 0.33 Published 1996 Journal Neuroimmunomodulation Section Abstract Doc Link 9266542 Disease Relevance 0.31 Pain Relevance 0.35
In contrast, morphine treatment had no effect on PMA/calcium ionophore (A23187)-induced increase in IL-2 secretion, suggesting a selective inhibition of IL-2R expression.
Positive_regulation (induced) of Localization (secretion) of IL-2 associated with morphine
5) Confidence 0.31 Published 1993 Journal Life Sci. Section Abstract Doc Link 8098501 Disease Relevance 0 Pain Relevance 1.27
We observed that the oral administration of FMSpH6 increased the number of IL-2+ and TNF?
Positive_regulation (increased) of Localization (number) of IL-2
6) Confidence 0.26 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2045662 Disease Relevance 0.06 Pain Relevance 0.04
Confirmatory studies specifically examining plasma IL-2, IL-2R and eotaxin-1 were conducted on an additional 17 stable and 6 rapidly progressive COPD subjects.
Positive_regulation (conducted) of Spec (examining) Localization (examining) of IL-2 in plasma associated with pulmonary disease
7) Confidence 0.22 Published 2009 Journal Respir Res Section Body Doc Link PMC2785783 Disease Relevance 1.19 Pain Relevance 0.21
The objective of this paper was to learn if the in vitro secretion of IL-2 and IFN-gamma and the release of sIL-2R by Oncomice spleen and thymus cells depended on the presence of the oncogene product, on the in vivo pretreatment with cocaine, or on the in vitro treatment with cocaine or morphine.
Positive_regulation (depended) of Localization (secretion) of IL-2 in thymus associated with morphine and cocaine
8) Confidence 0.21 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792019 Disease Relevance 0.27 Pain Relevance 0.26
In contrast, morphine treatment had no effect on PMA/calcium ionophore (A23187)-induced increase in IL-2 secretion, suggesting a selective inhibition of IL-2R expression.
Positive_regulation (increase) of Localization (secretion) of IL-2 associated with morphine
9) Confidence 0.21 Published 1993 Journal Life Sci. Section Abstract Doc Link 8098501 Disease Relevance 0 Pain Relevance 1.27
Phase 2 consists of recognition of bacterial antigens by CD4 lymphocytes, which release mainly IL-2 and IFN-?
Positive_regulation (mainly) of Localization (release) of IL-2 in lymphocytes
10) Confidence 0.12 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.49 Pain Relevance 0.28
Furthermore, M2 protein expression in primary murine B cells drives high level IL-10 expression along with increased secretion of IL-2, IL-6, and MIP-1?.
Positive_regulation (increased) of Localization (secretion) of IL-2 in B cells
11) Confidence 0.11 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2270344 Disease Relevance 0.55 Pain Relevance 0
Patients with early RA had significantly elevated synovial levels of IL-2, IL-4, IL-13, IL-17, EGF and bFGF when compared with patients with established RA (Figs 1 and 2, and Table 2).
Positive_regulation (elevated) of Localization (levels) of IL-2 associated with rheumatoid arthritis
12) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175027 Disease Relevance 2.21 Pain Relevance 0.94
IL-2 secreted by Ag-stimulated splenic CD4+ T cells from infected mice that received control Ab was significantly higher than levels from cells isolated from similar mice that received anti-CCL5 Ab or uninfected mice (Figure 4).
Positive_regulation (stimulated) of Localization (secreted) of IL-2 in T cells
13) Confidence 0.07 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.56 Pain Relevance 0.09
The objective of this paper was to learn if the in vitro secretion of IL-2 and IFN-gamma and the release of sIL-2R by Oncomice spleen and thymus cells depended on the presence of the oncogene product, on the in vivo pretreatment with cocaine, or on the in vitro treatment with cocaine or morphine.
Positive_regulation (depended) of in spleen Localization (secretion) of IL-2 in thymus associated with morphine and cocaine
14) Confidence 0.07 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792019 Disease Relevance 0.27 Pain Relevance 0.26
Phase 2 consists of recognition of bacterial antigens by CD4+ lymphocytes, which release mainly IL-2 and IFN-?
Positive_regulation (mainly) of Localization (release) of IL-2 in lymphocytes
15) Confidence 0.04 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.48 Pain Relevance 0.25
low response of KIRs to IL-2 suggests that patients with RA
Positive_regulation (suggests) of Localization (response) of IL-2 associated with rheumatoid arthritis
16) Confidence 0.03 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 1.46 Pain Relevance 0.49
TTNPB, indirectly increased proliferation of human T lymphocytes and IL-2
Positive_regulation (increased) of Localization (proliferation) of IL-2 in T lymphocytes
17) Confidence 0.03 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.47 Pain Relevance 0.46

General Comments

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