INT25386

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Context Info
Confidence 0.62
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 13.91
Pain Relevance 3.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd3e) signal transducer activity (Cd3e)
Anatomy Link Frequency
T cells 11
lymphocytes 2
macrophage 1
leukocytes 1
bone marrow 1
Cd3e (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 350 98.02 Very High Very High Very High
analgesia 2 96.28 Very High Very High Very High
cytokine 275 96.20 Very High Very High Very High
depression 2 91.28 High High
Pain 13 88.60 High High
Analgesic 1 87.24 High High
rheumatoid arthritis 224 86.60 High High
Infliximab 19 84.12 Quite High
corticosteroid 46 83.48 Quite High
tolerance 24 81.72 Quite High
Disease Link Frequency Relevance Heat
Influenza Virus Infection 70 99.98 Very High Very High Very High
Infection 147 99.90 Very High Very High Very High
Injury 77 99.62 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 138 99.52 Very High Very High Very High
Stomach Cancer 3 99.08 Very High Very High Very High
INFLAMMATION 325 98.02 Very High Very High Very High
Disease Progression 10 97.84 Very High Very High Very High
Autoimmune Disease 76 97.46 Very High Very High Very High
Syndrome 17 97.22 Very High Very High Very High
Sprains And Strains 50 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the 4 mg/kg of A. camphorata decreased the levels of CD11b and both doses of treatment increased CD3 and CD19.
Positive_regulation (increased) of CD3
1) Confidence 0.62 Published 2010 Journal Nutr Cancer Section Abstract Doc Link 20574920 Disease Relevance 0.64 Pain Relevance 0.07
A prospective randomized controlled trial was designed to observe expressions of T-lymphocyte subsets (CD3(+), CD3(+)CD4(+) and CD3(+)CD8(+)), natural-killer cells (CD3(-)CD16(+)CD56(+)), and activated T-lymphocytes (CD3(+)CD25(+)) of patients undergoing gastric cancer surgeries and receiving patient-controlled intravenous analgesia (PCIA).
Positive_regulation (activated) of CD3 in T-lymphocytes associated with stomach cancer and analgesia
2) Confidence 0.43 Published 2006 Journal Clin. Chim. Acta Section Abstract Doc Link 16487501 Disease Relevance 0.35 Pain Relevance 0.66
Quantification of inflammatory cells in wounds showed that allo-fibroblast- but not allo-BM-MSC-treated wounds had significantly increased CD45+ leukocytes, CD3+ lymphocytes and CD8+ T cells.
Positive_regulation (increased) of CD3 in leukocytes associated with inflammation and injury
3) Confidence 0.36 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2743192 Disease Relevance 0.84 Pain Relevance 0.05
However, when data were stratified according to validated EULAR clinical response criteria we found that at 30 weeks the best clinical outcomes were associated with an accumulation in the percent CD3+TCR?
Positive_regulation (accumulation) of CD3
4) Confidence 0.35 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.33 Pain Relevance 0.11
The CD11a(lo) population of splenocytes from the tick-infested mice was positive for TER-119 but negative for CD3, B220, CD11b and Gr, confirming that the splenocytes were members of the erythroid lineage.
Positive_regulation (negative) of CD3
5) Confidence 0.34 Published 2005 Journal Ann Trop Med Parasitol Section Abstract Doc Link 16004711 Disease Relevance 0.33 Pain Relevance 0
We have found that PGE2 and PGE1, but not PGF2 alpha, inhibit both proliferation and production of granulocyte-macrophage (GM)-CSF by murine TH clones stimulated with Ag or anti-CD3 antibody.
Positive_regulation (stimulated) of CD3 in macrophage
6) Confidence 0.29 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2521509 Disease Relevance 0 Pain Relevance 0.04
Again CD11c expression was much lower in MLN, spleen or blood and was not increased on CD3+CD8- cells (data not shown).
Neg (not) Positive_regulation (increased) of CD3 in spleen
7) Confidence 0.26 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 1.20 Pain Relevance 0.12
The results from multivariable linear regression model adjusted for year of birth and district show that total PAH exposure during the first two months of gestation was associated with increased T lymphocyte fractions CD3+ and CD4+ but not with CD8+.
Neg (not) Positive_regulation (increased) of CD3 in T lymphocyte
8) Confidence 0.26 Published 2010 Journal Environ Health Section Body Doc Link PMC2927516 Disease Relevance 0 Pain Relevance 0
We hypothesize that the immune systems of the surviving recipient mice transplanted with 2×106 allogeneic bone marrow cells are triggered by the graft and endogenous CD3+ lymphocytes are activated.
Positive_regulation (activated) of CD3 in bone marrow
9) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.36 Pain Relevance 0
After allogeneic bone marrow transplantation, flow cytometric analysis showed very few non-CD3+ lymphocytes and a high proportion of CD3+ lymphocytes in surviving mice.
Positive_regulation (proportion) of CD3 in lymphocytes
10) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.61 Pain Relevance 0
production by this population, although FOXP3 levels were reduced within the CD4+CD25+ population after anti-CD3/CD28 stimulation (Fig. 6a).
Positive_regulation (stimulation) of CD3
11) Confidence 0.21 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.37 Pain Relevance 0.08
We thus investigated caspases-3, -8 and -9 activity in Gal-4 treated anti-CD3/CD28 stimulated PBT using fluorogenic substrate assays.
Positive_regulation (stimulated) of CD3
12) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.95 Pain Relevance 0.03
The CD3 receptor complex is required for cell-surface expression of the antigen-binding chains and signaling.
Positive_regulation (required) of CD3
13) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0
Determination of Gal-4 binding to T cells was performed by incubating resting and for 48 h CD3/CD28-stimulated PBT and CD2-stimulated LPT with 5 µg/ml Gal-4, a dose not able to induce T cell apoptosis.
Positive_regulation (stimulated) of CD3 in T cells associated with apoptosis
14) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.15 Pain Relevance 0.06
At 9 weeks and 8 months post infection, an increase of the number of T cells (CD3-positive) was observed in the fundus of infected animals of both mice strains (Figure 2A).
Positive_regulation (increase) of CD3 in fundus associated with sprains and strains and infection
15) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2989923 Disease Relevance 1.04 Pain Relevance 0.29
CD3+ T cell lysates were collected in lysis buffer (10 mM Tris,pH 7.4, 1 mM sodium orthovanadate, 1% SDS), sonicated and frozen at ?
Positive_regulation (lysates) of CD3 in T cell
16) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.51 Pain Relevance 0.22
In humans, before treatment with androgens, patients who have Klinefelter's syndrome but not RAD have very diminished levels of testosterone associated with high levels of IgG, IgA, IgM, IL-2, and IL-4 and with an absolute increase of CD3+, CD4+, and the CD4+/CD8+ ratio [30].
Positive_regulation (increase) of CD3 associated with autoimmune disease and syndrome
17) Confidence 0.09 Published 2001 Journal Arthritis Res Section Body Doc Link PMC64847 Disease Relevance 0.71 Pain Relevance 0.03
, TNF mAb1 and mAb11, and for the presence of the cell surface markers CD3, CD19, CD20, CD68 and CD163, as described previously [14].
Positive_regulation (markers) of CD3
18) Confidence 0.08 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 0.06 Pain Relevance 0.15
As part of a retrospective study comparing muromonab CD3 vs basiliximab induction and triple therapy, Kode and colleagues (2003) compared the outcome at three months post-transplant in patients younger or older than 60 years of age in those receiving basiliximab.
Positive_regulation (induction) of CD3
19) Confidence 0.08 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721359 Disease Relevance 0.34 Pain Relevance 0.13
We sorted CD3+CD4+ and CD3+CD8+ T cells to 98% purity from cryopreserved PBMC on a FACS Vantage (BDIS).
Positive_regulation (sorted) of CD3 in T cells
20) Confidence 0.08 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0

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