INT25387

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1989
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 42
Total Number 45
Disease Relevance 16.00
Pain Relevance 7.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger2) plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
PGE2 3
macrophages 2
neutrophils 2
MDA-MB-468 1
MDA-MB-231 1
Ptger2 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 81 99.20 Very High Very High Very High
Thermal hyperalgesia 45 98.88 Very High Very High Very High
qutenza 150 98.82 Very High Very High Very High
Inflammation 262 97.68 Very High Very High Very High
long-term potentiation 146 97.60 Very High Very High Very High
Pain 65 97.04 Very High Very High Very High
antagonist 416 96.44 Very High Very High Very High
addiction 7 94.00 High High
agonist 154 93.68 High High
Nerve growth factor 4 92.68 High High
Disease Link Frequency Relevance Heat
Ovarian Cancer 45 99.64 Very High Very High Very High
Ganglion Cysts 98 99.20 Very High Very High Very High
Hyperalgesia 54 98.88 Very High Very High Very High
Cancer 557 98.68 Very High Very High Very High
Necrosis 291 98.28 Very High Very High Very High
Fever 29 98.12 Very High Very High Very High
Infection 558 97.84 Very High Very High Very High
INFLAMMATION 359 97.68 Very High Very High Very High
Pain 72 97.04 Very High Very High Very High
Death 142 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EP2 and EP4 are reported to couple exclusively with G?
EP2 Binding (couple) of
1) Confidence 0.47 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
ONO-AE1-259-01 has no detectable affinity to any other prostaglandin receptor [11] and binds with higher affinity to the EP2 receptor (Ki = 3 nM) than does PGE1, 16,16-dimethyl-PGE2, 11-deoxy-PGE1, butaprost, or AH-6809 (Ki = 10, 17, 45, 110, and 350 nM, respectively) [5,6,12].


EP2 receptor Binding (binds) of
2) Confidence 0.36 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.37 Pain Relevance 0.14
PGE2 executes its functions by binding mainly to four membrane-bound G-protein-coupled receptors known as E-prostanoid (EP) 1, 2, 3, and 4.
PGE2 Binding (binding) of in PGE2
3) Confidence 0.31 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.28 Pain Relevance 0.14
EP receptors utilize G proteins to mediate the effect of PGE2 binding to these transmembrane receptors [7].
PGE2 Binding (binding) of
4) Confidence 0.30 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
While PGE2 acts at both cumulus and mural granulosa cells of ovulatory follicles to promote periovulatory events [10,11], comparatively little is known about the oocyte as a target for PGE2 action.
PGE2 Binding (target) of in granulosa cells
5) Confidence 0.30 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0.07 Pain Relevance 0
PGE2 acts by interacting with four subtypes of PGE receptor, the EP1, EP2, EP3 and EP4 receptors.
EP2 Binding (interacting) of in PGE2
6) Confidence 0.29 Published 1998 Journal Nature Section Abstract Doc Link 9751056 Disease Relevance 0.85 Pain Relevance 0.22
This involves interesting and efficient trafficking of EP2 and EP3, both of which are located at the postsynaptic sites in the neurons of the visual cortex.
EP2 Binding (trafficking) of in cortex
7) Confidence 0.28 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.52
Bidirectional trafficking of the two subtypes, EP2 and EP3, which have reciprocal actions is one of the ways by which synaptic functions may be regulated.
EP2 Binding (trafficking) of
8) Confidence 0.28 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.20 Pain Relevance 0.03
This bidirectional trafficking of EP2 and EP3 is similar to the trafficking of AMPA receptors in LTP.
EP2 Binding (trafficking) of associated with long-term potentiation
9) Confidence 0.28 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.25
After immunostaining for EP2, the nuclei were counterstained with 4,6-diamidino,2-phenylindole dihydrochloride (DAPI; 1 ?
EP2 Binding (immunostaining) of
10) Confidence 0.26 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0 Pain Relevance 0.19
Although we definitively confirm the role of PGE2 and more precisely define its mechanistic activity by identifying EP2 as the crucial PGE2 receptor, these findings beg for further dissection of this important signaling pathway leading to increased M?
PGE2 Binding (receptor) of
11) Confidence 0.26 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.19 Pain Relevance 0.15
EP2 is associated with activation of protein kinase A (PKA) (49–51).
EP2 Binding (associated) of
12) Confidence 0.26 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0 Pain Relevance 0
Receptors for PGE2
PGE2 Binding (Receptors) of
13) Confidence 0.24 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.07 Pain Relevance 0.03
The dynamic force causing this trafficking might be provided by as yet unknown EP2- and EP3-interacting proteins, similar to the AMPA receptor-interacting proteins involved in the so-called silent synapse mechanisms (Harris and Lim, 2001; Barry and Ziff, 2002; Collingridge et al. 2004).
EP2 Binding (interacting) of in synapse
14) Confidence 0.23 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.19
The EP2 subtype couples to G protein ?
EP2 Binding (couples) of
15) Confidence 0.22 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.10 Pain Relevance 0.11
Prostanoids are lipid mediators generated from AA by the enzymatic action of the cyclooxygenases (COX) 1 and 2 to form the intermediate PGH2, with subsequent metabolism to specific prostanoid species (e.g., PGD2, PGE2, PGF2?
PGE2 Binding (metabolism) of
16) Confidence 0.22 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0.72 Pain Relevance 0.12
PGE2 acts by engaging the PGE2 receptor EP2, which induces cyclic AMP production and protein kinase A activation.
EP2 Binding (engaging) of
17) Confidence 0.21 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2585850 Disease Relevance 1.46 Pain Relevance 0.04
On the other hand, the PGE2-induced thermal hyperalgesia was almost completely abolished in TRPV1-/- mice, suggesting a functional interaction between PGE2 and TRPV1 (Figure 1A), consistent with a previous report that capsaicin-ablation of primary afferent neurons prevents PGE2-induced thermal hyperalgesia [23].
PGE2 Binding (interaction) of in afferent neurons associated with qutenza and thermal hyperalgesia
18) Confidence 0.19 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.57 Pain Relevance 0.86
We next examined the interaction between PGE2 and TRPV1 in mouse DRG neurons using the patch-clamp technique.
PGE2 Spec (examined) Binding (interaction) of in neurons associated with dorsal root ganglion
19) Confidence 0.19 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.59 Pain Relevance 0.90
The capsaicin-evoked currents were significantly potentiated by 1.5 min pretreatment with PGE2 (1?
PGE2 Binding (pretreatment) of associated with qutenza
20) Confidence 0.19 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.69 Pain Relevance 0.95

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox