INT253918

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.61
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Rnf123) ligase activity (Rnf123) biological_process (Rnf123)
cytoplasm (Rnf123)
Anatomy Link Frequency
muscle 2
myotubes 2
Rnf123 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 27 94.56 High High
Inflammation 112 88.44 High High
agonist 2 22.80 Low Low
Inflammatory response 7 8.96 Low Low
Hippocampus 15 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Demyelination 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 12 99.92 Very High Very High Very High
Muscular Atrophy 26 98.40 Very High Very High Very High
Frailty 40 98.38 Very High Very High Very High
Congenital Anomalies 43 93.76 High High
Pathologic Processes 1 88.64 High High
INFLAMMATION 119 88.44 High High
Cancer 87 87.48 High High
Appetite Loss 42 85.32 High High
Hypertrophy 6 56.72 Quite High
Body Weight 13 53.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ubiquitin ligase expression is increased, likely reflecting effects on host cell protein processing.


Spec (likely) Positive_regulation (increased) of Gene_expression (expression) of Ubiquitin ligase
1) Confidence 0.07 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.54 Pain Relevance 0.14
In C2C12 myotubes, ERK inhibition appeared required to stimulate ubiquitin ligase expression [13].
Positive_regulation (stimulate) of Gene_expression (expression) of ubiquitin ligase in myotubes
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.53 Pain Relevance 0.07
To ascertain if PD prevents muscle wasting by downregulating the UPS, protein levels of atrogin-1/MAFbx, a muscle-specific ubiquitin ligase overexpressed in pathological states associated with muscle atrophy [4], [7], were evaluated.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ubiquitin ligase in muscle associated with frailty and muscular atrophy
3) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.54 Pain Relevance 0.04

General Comments

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