INT25392

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Context Info
Confidence 0.49
First Reported 1989
Last Reported 2011
Negated 4
Speculated 2
Reported most in Body
Documents 41
Total Number 44
Disease Relevance 34.28
Pain Relevance 8.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
macrophage 9
T cell 4
frontal cortex 4
brain 2
osteoclast 2
Csf2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 543 100.00 Very High Very High Very High
Inflammation 490 100.00 Very High Very High Very High
Multiple sclerosis 173 100.00 Very High Very High Very High
chemokine 97 100.00 Very High Very High Very High
gABA 58 100.00 Very High Very High Very High
rheumatoid arthritis 160 99.52 Very High Very High Very High
Glutamate 41 99.44 Very High Very High Very High
Osteoarthritis 35 99.24 Very High Very High Very High
addiction 3 98.40 Very High Very High Very High
Morphine 8 98.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 530 100.00 Very High Very High Very High
Demyelinating Disease 182 100.00 Very High Very High Very High
Pulmonary Alveolar Proteinosis 178 100.00 Very High Very High Very High
Disease 366 99.78 Very High Very High Very High
Injury 33 99.74 Very High Very High Very High
Glioma 29 99.68 Very High Very High Very High
Necrosis 44 99.62 Very High Very High Very High
Cancer 1341 99.58 Very High Very High Very High
Rheumatoid Arthritis 163 99.52 Very High Very High Very High
Retinoblastoma 6 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When incremental doses of GM-CSF (0, 1, 10, or 100 ng/mL) were added to high doses of LPS (100 ng/mL), the expression of TNF-?
Positive_regulation (incremental) of Gene_expression (doses) of GM-CSF
1) Confidence 0.49 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526424 Disease Relevance 0.26 Pain Relevance 0.36
DISC-HSV-2 has been shown to be an efficient vector for cytokine gene delivery into tumour cells, and that the expression of mGM-CSF or hIL-2 enhances the immunogenicity of whole-cell vaccines [108, 109].
Positive_regulation (enhances) of Gene_expression (expression) of GM-CSF associated with cold sores, cancer and cytokine
2) Confidence 0.49 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.32 Pain Relevance 0.05
Dependence on PGE2 for this response was not found in all clones, as some TH1 cells could produce GM-CSF after IL-2 alone, and some cells did not produce GM-CSF even in the presence of PGE2 and IL-2.
Positive_regulation (after) of Gene_expression (produce) of GM-CSF associated with addiction
3) Confidence 0.47 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2521509 Disease Relevance 0.07 Pain Relevance 0.05
Here, we report the effects of morphine on purified approximately 12-kDa component of Leishmania donovani amastigote antigen (LDAA-12)-induced colony-stimulating factor (CSF) production by mouse peritoneal macrophages (PMs) in vitro.
Positive_regulation (-induced) of Gene_expression (production) of CSF in PMs associated with morphine
4) Confidence 0.45 Published 2005 Journal Microbes Infect. Section Abstract Doc Link 15716055 Disease Relevance 0.19 Pain Relevance 0.49
Following each vaccination GM-CSF (Leukine®, Berlex Laboratories Inc., Richmond, CA, USA) was infused subcutaneously at the vaccination site for 6 full days at a rate 50 ?
Positive_regulation (Following) of Gene_expression (infused) of GM-CSF
5) Confidence 0.40 Published 2007 Journal J Transl Med Section Body Doc Link PMC2020458 Disease Relevance 0.74 Pain Relevance 0
Furthermore, a threshold effect for vaccine GM-CSF production on survival was noted in these trials, with longer survival seen in patients receiving vaccines secreting >40 ng GM-CSF/106 cells/24 h [3].
Positive_regulation (effect) of Gene_expression (production) of GM-CSF
6) Confidence 0.40 Published 2007 Journal J Transl Med Section Body Doc Link PMC2020458 Disease Relevance 1.10 Pain Relevance 0
Furthermore, a threshold effect for vaccine GM-CSF production on survival was noted in these trials, with longer survival seen in patients receiving vaccines secreting >40 ng GM-CSF/106 cells/24 h [3].
Positive_regulation (vaccine) of Gene_expression (production) of GM-CSF
7) Confidence 0.40 Published 2007 Journal J Transl Med Section Body Doc Link PMC2020458 Disease Relevance 1.10 Pain Relevance 0
Following each vaccination GM-CSF (Leukine®, Berlex Laboratories Inc., Richmond, CA, USA) was infused subcutaneously at the vaccination site for 6 full days at a rate 50 ?
Positive_regulation (vaccination) of Gene_expression (infused) of GM-CSF
8) Confidence 0.40 Published 2007 Journal J Transl Med Section Body Doc Link PMC2020458 Disease Relevance 0.74 Pain Relevance 0
Significant increases in cytokines, such as interleukin (IL)-1beta, IL-6 and granulocyte macrophage colony stimulating factor (GM-CSF), and in chemokines, such as macrophage chemotactic protein 1 (MCP-1), macrophage inflammatory protein 1 (MIP-1alpha) and Kupffer cell derived chemokine (KC), were detected, with no changes in T-cell-derived cytokines.
Positive_regulation (increases) of Neg (no) Gene_expression (detected) of GM-CSF in Kupffer cell associated with chemokine, inflammation and cytokine
9) Confidence 0.38 Published 2007 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17509021 Disease Relevance 0.57 Pain Relevance 0.72
The mean CSF ABC concentration increased consistently between the first and last collection intervals (0.126 ?
Positive_regulation (increased) of Gene_expression (concentration) of CSF
10) Confidence 0.34 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1845158 Disease Relevance 0.33 Pain Relevance 0
While peak CSF concentrations may not have been attained due to the limited collection period (4 h post-dose in a 12-h dosing interval), the observed peak values are 9-fold greater than a representative IC50 for ABC (0.08 ?
Positive_regulation (peak) of Gene_expression (concentrations) of CSF
11) Confidence 0.34 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1845158 Disease Relevance 0.20 Pain Relevance 0
The mean CSF ABC concentration increased consistently between the first and last collection intervals (0.126 ?
Positive_regulation (mean) of Gene_expression (concentration) of CSF
12) Confidence 0.34 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1845158 Disease Relevance 0.33 Pain Relevance 0
Spinal cords from recipients of IL-23–modulated cells expressed elevated levels of G-CSF, a neutrophil activation and growth factor (Fig. 4 C).
Positive_regulation (elevated) of Gene_expression (expressed) of CSF in neutrophil
13) Confidence 0.29 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 1.09 Pain Relevance 0.31
, inhibits osteoclast formation via increased production of GM-CSF by T cells and osteoblasts [20,21].
Positive_regulation (increased) of Gene_expression (production) of GM-CSF in osteoclast
14) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.57 Pain Relevance 0.26
IL-1-dependent production of IL-6, IL-8, and GM-CSF in FLS is critically dependent upon activation and nuclear translocation of NF-?
Positive_regulation (dependent) of Gene_expression (production) of GM-CSF
15) Confidence 0.27 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416442 Disease Relevance 0.80 Pain Relevance 0.33
In vitro experiments were conducted to determine the effect on the IL-1-induced production of IL-6, IL-8, and granulocyte/macrophage-colony-stimulating factor (GM-CSF) by FLS in RA and osteoarthritis (OA).
Positive_regulation (induced) of Gene_expression (production) of GM-CSF in macrophage associated with rheumatoid arthritis and osteoarthritis
16) Confidence 0.27 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416442 Disease Relevance 0.87 Pain Relevance 0.36
These GBM-M2 lines grew more aggressively orthotopically and all showed dramatic multifold increases in IL6, IL8, MCP-1 and GM-CSF expression, cytokines and factors that are associated with GBM and poor prognosis.
Positive_regulation (increases) of Gene_expression (expression) of GM-CSF in GBM associated with glioblastoma and cytokine
17) Confidence 0.27 Published 2008 Journal J Transl Med Section Abstract Doc Link PMC2645376 Disease Relevance 1.74 Pain Relevance 0.12
The site and mechanism of action of pioglitazone – whether it stimulates CSF production or inhibits its reabsorption – remain to be investigated.
Positive_regulation (stimulates) of Gene_expression (production) of CSF
18) Confidence 0.24 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC500868 Disease Relevance 1.08 Pain Relevance 0.24
However, caution is warranted with the use of IL-18-binding protein because it may lower the production of GM-CSF and IFN-?
Spec (may) Positive_regulation (lower) of Gene_expression (production) of GM-CSF
19) Confidence 0.22 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128900 Disease Relevance 0.94 Pain Relevance 0.54
This particular adenovirus selectively targets cells with p16/RB pathway dysfunction and stimulates the production of granulocyte-macrophage colony-stimulating factor (GM-CSF), an immune modulator that locally induces CD8+ T cell and natural killer (NK) cell activity.
Positive_regulation (stimulates) of Gene_expression (production) of GM-CSF in T cell associated with retinoblastoma
20) Confidence 0.18 Published 2011 Journal Sarcoma Section Body Doc Link PMC3018623 Disease Relevance 1.06 Pain Relevance 0

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