INT253922

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 1.21
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Otc) cellular amino acid metabolic process (Otc) cytoplasm (Otc)
Anatomy Link Frequency
liver 4
CAR 2
brains 2
gut 1
body 1
Otc (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 72 88.20 High High
Bile 135 86.40 High High
agonist 30 85.20 High High
imagery 30 67.40 Quite High
Demyelination 12 56.80 Quite High
Inflammation 353 50.00 Quite Low
Pain 18 40.92 Quite Low
pain insensitivity 3 37.64 Quite Low
Hippocampus 45 5.00 Very Low Very Low Very Low
cytokine 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 93 100.00 Very High Very High Very High
Cyst 180 95.00 High High
Infection 243 90.88 High High
Alzheimer's Dementia 14 61.12 Quite High
Congenital Anomalies 129 60.48 Quite High
Demyelinating Disease 18 56.80 Quite High
INFLAMMATION 376 50.00 Quite Low
Injury 25 50.00 Quite Low
Pain 21 40.92 Quite Low
Obesity 41 19.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
governs metabolism of amino acids by suppressing expression of genes involved in transamination (Aspartate amino transferase (Got1), Alanine amino transferase (Gpt), Alanine glyoxylate aminotransferase (Agtx2), and deamination (Glutaminase (Gls)), as well as numerous genes that are part of the urea cycle (Cps1, Otc, Ass1, and Asl) [160, 161, 245].
Gene_expression (expression) of Otc
1) Confidence 0.17 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0 Pain Relevance 0.14
Interestingly, while the NR FXR was more highly expressed in the GF, compared to SPF mice, no significant difference in expression of PXR was detected indicating that the xenobiotic NRs involved may be differentially regulated by the gut flora.
Gene_expression (expressed) of SPF in gut
2) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.15
Cyp2b9, a major P450 in the mouse liver was 46.5-fold lower expressed in the SPF compared to GF mice.
Gene_expression (expressed) of SPF in liver
3) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0
Our observed association between lower expression of POR and the three PAR bZip genes; Dbp, Tef and Hlf, and the higher liver/body weight ratio in SPF are consistent with results from hepatic POR null mice [27] and PAR bZip triple knockouts [23] where the liver/body weight ratios are increased, most likely because of accumulation of lipids.
Gene_expression (expression) of SPF in body associated with body weight
4) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.29 Pain Relevance 0
CAR was more highly expressed in the livers of GF compared to SPF mice, and several CAR-regulated genes were differentially expressed in the same direction.
Gene_expression (expressed) of SPF in livers
5) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.14 Pain Relevance 0.10
CAR was 1.6-fold lower expressed in the SPF compared to GF mice, and several CAR-regulated genes were differentially expressed in the same direction.
Gene_expression (expressed) of SPF in CAR
6) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0
In addition, the CAR-regulated gene POR, coding for the P450 oxidoreductase, the unique electron donor for all type II cytochrome P450 enzymes, was more highly expressed in the GF animals compared to SPF.
Gene_expression (expressed) of SPF in CAR
7) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.06 Pain Relevance 0.13
7 mice/group), and 112 genes were verified to be significantly differentially expressed (q<5%) in GF compared to SPF livers (Table S1).
Gene_expression (expressed) of SPF in livers
8) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0
The NR farnesoid-X receptor, FXR was also 1.3-fold lower expressed in the SPF compared to GF mice.
Gene_expression (expressed) of SPF
9) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0
The RNA from the brains of three SPF, SW mice infected with T. gondii for a minimum of one year and three uninfected SPF, SW control mice bred and housed from birth in the same colony were extracted using trizol (Invitrogen, Carlsbad, CA).
Gene_expression (brains) of SPF in brains
10) Confidence 0.09 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.06 Pain Relevance 0.09
The RNA from the brains of three SPF, SW mice infected with T. gondii for a minimum of one year and three uninfected SPF, SW control mice bred and housed from birth in the same colony were extracted using trizol (Invitrogen, Carlsbad, CA).
Gene_expression (brains) of SPF in brains
11) Confidence 0.09 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.06 Pain Relevance 0.09
The images of these sections were prepared as described previously for the manuscript using non-SPF, SW mice that were chronically infected with T. gondii [83].
Gene_expression (infected) of SPF
12) Confidence 0.09 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.30 Pain Relevance 0.03
Our observed association between lower expression of POR and the three PAR bZip genes; Dbp, Tef and Hlf, and the higher liver/body weight ratio in SPF are consistent with results from hepatic POR null mice [27] and PAR bZip triple knockouts [23] where the liver/body weight ratios are increased, most likely because of accumulation of lipids.
Gene_expression (expression) of SPF in liver associated with body weight
13) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.29 Pain Relevance 0

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