INT253925

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 5.03
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 2
brain 2
effector T cells 2
T cells 2
Pdcd1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 57 100.00 Very High Very High Very High
agonist 18 99.36 Very High Very High Very High
Inflammation 440 99.24 Very High Very High Very High
Hippocampus 60 70.24 Quite High
Inflammatory response 28 21.08 Low Low
imagery 40 5.00 Very Low Very Low Very Low
Pain 24 5.00 Very Low Very Low Very Low
Demyelination 16 5.00 Very Low Very Low Very Low
depression 12 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diffuse Cutaneous Leishmaniasis 222 100.00 Very High Very High Very High
Death 65 100.00 Very High Very High Very High
INFLAMMATION 468 99.24 Very High Very High Very High
Cyst 240 99.24 Very High Very High Very High
Toxoplasmosis 36 97.92 Very High Very High Very High
Infection 378 95.64 Very High Very High Very High
Leishmaniasis 150 95.00 High High
Disease 112 93.12 High High
Injury 32 92.48 High High
Sprains And Strains 44 83.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since exhausted T cells have been shown to have increased expression of programmed death-1 (PD-1) molecules, which could be modified by TLR-9 ligand, we analyzed if PD-1 expression in CD8 cells of DCL patients could be modified by TLR2 agonists.
Positive_regulation (increased) of Gene_expression (expression) of PD-1 in T cells associated with agonist, diffuse cutaneous leishmaniasis and death
1) Confidence 0.06 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.70 Pain Relevance 0.12
Although CD8 exhaustion has not been reported in patients with leishmaniasis, our results on “functional exhaustion” is in accordance with the literature since Joshi and coworkers could demonstrate that L. donovani limits CD8 expansion and induces functional exhaustion in an experimental model [16] which was associated with increased PD-1 expression by Leishmania-specific CD8.
Positive_regulation (increased) of Gene_expression (expression) of PD-1 associated with leishmaniasis
2) Confidence 0.06 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.40 Pain Relevance 0.03
We found that PD-1 expression in CD8+ of DCL patients was significantly reduced after stimulation with both TLR2 agonists, LPG (p?
Positive_regulation (after) of Gene_expression (expression) of PD-1 associated with agonist and diffuse cutaneous leishmaniasis
3) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.63 Pain Relevance 0.14
Because there was increased expression of PD-1L in whole genome microarrays, and this is a ligand that allows persistent Lymphochoriomeningitis virus brain infection by limiting activity of T cells, hamster antibody to PD-1L or isotype-control was administered every 7 days for 21 days.
Positive_regulation (increased) of Gene_expression (expression) of PD-1L in brain associated with infection
4) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 1.09 Pain Relevance 0.30
Increased expression of PD-1L suggests that the inflammatory cells that are attracted into the brain may not always be fully functional effector T cells, as demonstrated in LCMV infection [86,109] when this is associated with diminished activity of T cells.
Positive_regulation (Increased) of Gene_expression (expression) of PD-1L in effector T cells associated with inflammation and infection
5) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.61 Pain Relevance 0.08
Microarrays provide insight into the molecular pathogenesis of the processes in the outbred mice reflecting inflammation, attenuation of this inflammation by counter regulatory processes, neuronal cell death and potential remodeling of synapses with increased expression of C1q, as well as CD36, immunoglobin genes, GFAP, and PD-1L in these transcriptomes.
Positive_regulation (increased) of Gene_expression (expression) of PD-1L in neuronal associated with inflammation and death
6) Confidence 0.03 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 1.14 Pain Relevance 0.29
In addition, there was increased expression of the Suppression of Cytokine Signaling (SOCS), CD36, and PD-1L genes and others including C1q.
Positive_regulation (increased) of Gene_expression (expression) of PD-1L associated with cytokine
7) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.46 Pain Relevance 0.13

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