INT25393

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Context Info
Confidence 0.32
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 9.69
Pain Relevance 3.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger2) plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
macrophage 4
spinal 2
tissue-resident macrophages 2
lung 2
A549 2
Ptger2 (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 5 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
Inflammation 129 99.70 Very High Very High Very High
Pain 30 99.70 Very High Very High Very High
qutenza 50 99.54 Very High Very High Very High
IPN 6 98.20 Very High Very High Very High
addiction 1 98.10 Very High Very High Very High
Spinal cord 17 97.24 Very High Very High Very High
COX-2 inhibitor 12 96.90 Very High Very High Very High
cINOD 32 94.36 High High
Disease Link Frequency Relevance Heat
Hemophilus Infection 356 99.98 Very High Very High Very High
Middle Cerebral Artery Infarction 37 99.56 Very High Very High Very High
Ulcers 33 99.10 Very High Very High Very High
Cicatrix 14 98.46 Very High Very High Very High
Burns 5 98.34 Very High Very High Very High
Inflammatory Pain 6 98.20 Very High Very High Very High
Hypertrophy 2 97.94 Very High Very High Very High
Peptic Ulcer 6 97.88 Very High Very High Very High
Stress 29 95.84 Very High Very High Very High
INFLAMMATION 172 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
stimulate PGE2 release up to 33-fold of control in response to
Positive_regulation (stimulate) of Localization (release) of PGE2
1) Confidence 0.32 Published 2009 Journal PPAR Research Section Body Doc Link PMC2651001 Disease Relevance 0.56 Pain Relevance 0
P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain.
Positive_regulation (mediate) of Localization (release) of PGE2 in tissue-resident macrophages associated with inflammation and ipn
2) Confidence 0.31 Published 2010 Journal EMBO J. Section Title Doc Link 20562826 Disease Relevance 1.10 Pain Relevance 1.16
These data clearly show that TRPV1 currents evoked by any of three different stimuli (capsaicin, proton, or heat) are potentiated or sensitized by PGE2 through EP1 receptor activation.
Positive_regulation (activation) of Localization (potentiated) of PGE2 associated with qutenza
3) Confidence 0.29 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0 Pain Relevance 0.30
2(b), treatment with increasing amounts of PGE2 resulted in a
Positive_regulation (increasing) of Localization (amounts) of PGE2
4) Confidence 0.23 Published 2009 Journal PPAR Research Section Body Doc Link PMC2651001 Disease Relevance 0 Pain Relevance 0
2(b), treatment with increasing amounts of PGE2 resulted in a
Positive_regulation (resulted) of Localization (amounts) of PGE2
5) Confidence 0.23 Published 2009 Journal PPAR Research Section Body Doc Link PMC2651001 Disease Relevance 0 Pain Relevance 0
Dependence on PGE2 for this response was not found in all clones, as some TH1 cells could produce GM-CSF after IL-2 alone, and some cells did not produce GM-CSF even in the presence of PGE2 and IL-2.
Positive_regulation (after) of Localization (presence) of PGE2 associated with addiction
6) Confidence 0.11 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2521509 Disease Relevance 0.08 Pain Relevance 0.05
was not mediated via activation of either of the endogenous EP2 or EP4 receptors or intracellular signaling cascades downstream of phospholipase C?
Positive_regulation (activation) of Localization (either) of EP2
7) Confidence 0.11 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.18 Pain Relevance 0.20
Thus, drugs that arrest ulcer progression by antioxidant action, and also promote secretion of PGE2, gastric mucus, and growth factors would accelerate gastric ulcer healing.
Positive_regulation (promote) of Localization (secretion) of PGE2 associated with ulcers and peptic ulcer
8) Confidence 0.08 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.61 Pain Relevance 0.15
However, co-stimulation with EGF and gastrin synergistically induced COX-2 protein and mRNA expression and PGE2 secretion.
Positive_regulation (induced) of Localization (secretion) of PGE2
9) Confidence 0.07 Published 2003 Journal J. Cell. Physiol. Section Abstract Doc Link 12891702 Disease Relevance 0.12 Pain Relevance 0.14
However 2 hours of MCAO caused a significant increase in the PGE2 concentration of both the contralateral and ipsilateral cPLA2?
Positive_regulation (increase) of Localization (concentration) of PGE2 associated with middle cerebral artery infarction
10) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2923122 Disease Relevance 0.54 Pain Relevance 0.22
716 mice, thus indicating that the induction of the COX-2/PGE2 pathway and subsequent macrophage infiltration are not sufficient for the promotion of Wnt/?
Positive_regulation (induction) of Localization (infiltration) of PGE2 in macrophage
11) Confidence 0.05 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.21 Pain Relevance 0
716 mice, thus indicating that the induction of the COX-2/PGE2 pathway and subsequent macrophage infiltration are not sufficient for the promotion of Wnt/?
Positive_regulation (subsequent) of Localization (infiltration) of PGE2 in macrophage
12) Confidence 0.05 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.16 Pain Relevance 0
PGE2 release evoked by intrathecal dynorphin requires spinal p38 activation [64]. p38 activation also causes a rapid release of IL-1?
Positive_regulation (requires) of Localization (release) of PGE2 in spinal associated with dynorphin and intrathecal
13) Confidence 0.04 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.35 Pain Relevance 0.52
These results indicated that PGE2 release depends on COX-2 activity, in line with the previous studies by Schmeck et al. and Rupp et al. [9,14].
Positive_regulation (depends) of Localization (release) of PGE2
14) Confidence 0.04 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 0.80 Pain Relevance 0.04
Furthermore, NTHi-induced PGE2 release was significantly suppressed by COX-2 specific inhibitor, but not COX-1 inhibitor.
Positive_regulation (induced) of Localization (release) of PGE2 associated with hemophilus infection
15) Confidence 0.03 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 0.87 Pain Relevance 0.04
Furthermore, the pre-treatment of selective COX-2 inhibitor NS398 significantly decreased NTHi-induced PGE2 production to baseline levels, but pre-treatment of selective COX-1 inhibitor SC560 has no effect on NTHi-induced PGE2 release in lung epithelial cells A549.
Positive_regulation (induced) of Localization (release) of PGE2 in lung associated with hemophilus infection and cox-2 inhibitor
16) Confidence 0.03 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.10 Pain Relevance 0.05
Result demonstrated that PGE2 release from A549 cells was significantly increased by NTHi (Fig. 2).
Positive_regulation (increased) of Localization (release) of PGE2 in A549 associated with hemophilus infection
17) Confidence 0.03 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 0.98 Pain Relevance 0.05
When BV-2 cells were stimulated with TPA, levels of secreted PGE2 were elevated by ~2-fold (Figure 6).
Positive_regulation (elevated) of Localization (secreted) of PGE2 in PGE2
18) Confidence 0.02 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.27 Pain Relevance 0.18
The best prevention and control of hypertrophy, especially in burn scars, is achieved using elastocompression, and compression induced a significant increase in the release of PGE2, in both the remission and active stages, suggesting a role for PGE2 in the process of hypertrophy remission induced by pressure therapy [38].
Positive_regulation (increase) of Localization (release) of PGE2 associated with cicatrix, hypertrophy and burns
19) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2910481 Disease Relevance 1.77 Pain Relevance 0.13

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