INT253938

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.40
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Gsk3a) kinase activity (Gsk3a)
Anatomy Link Frequency
skeletal muscle 1
adipose tissue 1
Gsk3a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 32 100.00 Very High Very High Very High
Kinase C 18 99.48 Very High Very High Very High
cytokine 2 95.92 Very High Very High Very High
alcohol 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Enkephalin 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 33 100.00 Very High Very High Very High
Insulin Resistance 20 98.04 Very High Very High Very High
Obesity 22 96.36 Very High Very High Very High
Disease 40 90.60 High High
Injury 3 88.40 High High
Metabolic Syndrome 106 86.88 High High
Alzheimer's Dementia 5 86.88 High High
Amyloid Plaque 4 55.68 Quite High
Hyperlipidemia 12 50.00 Quite Low
Cardiovascular Disease 42 47.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These adipokines lead to the systemic activation of several protein kinases involved in inflammatory signal transduction, including phosphoinositide-3 kinase (PI3K), glycogen synthase kinase (GSK-3) and PKC that singly or in concert cause insulin resistance in skeletal muscle and adipose tissue [22-24].
Positive_regulation (activation) of glycogen synthase kinase in skeletal muscle associated with kinase c, inflammation, obesity and insulin resistance
1) Confidence 0.06 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2588603 Disease Relevance 1.37 Pain Relevance 0.45
is thought to catalyze the formation of NFTs [84,92,93], affecting tau proteins through regulation of glycogen synthase kinase-3 (GSK3) activity [94,95] and activation of cyclin-dependent kinase 5 (CDK5) [96].
Positive_regulation (activation) of glycogen synthase kinase-3
2) Confidence 0.05 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.65 Pain Relevance 0
These adipokines lead to the systemic activation of several protein kinases involved in inflammatory signal transduction, including phosphoinositide-3 kinase (PI3K), glycogen synthase kinase (GSK-3) and PKC that singly or in concert cause insulin resistance in skeletal muscle and adipose tissue [22-24].
Positive_regulation (activation) of glycogen synthase kinase in adipose tissue associated with kinase c, inflammation, obesity and insulin resistance
3) Confidence 0.02 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2588603 Disease Relevance 1.37 Pain Relevance 0.45

General Comments

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