INT25394

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Context Info
Confidence 0.52
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 13.18
Pain Relevance 5.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
choroid plexus 4
frontal cortex 4
macrophage 2
myeloid dendritic cells 2
CSF 2
Csf2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 275 100.00 Very High Very High Very High
rheumatoid arthritis 149 100.00 Very High Very High Very High
gABA 63 100.00 Very High Very High Very High
Glutamate 35 100.00 Very High Very High Very High
agonist 20 99.98 Very High Very High Very High
Morphine 7 99.84 Very High Very High Very High
depression 1 99.76 Very High Very High Very High
Osteoarthritis 17 98.76 Very High Very High Very High
Inflammation 209 97.28 Very High Very High Very High
fluoxetine 3 96.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 153 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 147 99.84 Very High Very High Very High
Depression 1 99.76 Very High Very High Very High
Necrosis 101 99.70 Very High Very High Very High
Pulmonary Alveolar Proteinosis 34 99.38 Very High Very High Very High
Urological Neuroanatomy 11 99.12 Very High Very High Very High
Osteoarthritis 17 98.76 Very High Very High Very High
INFLAMMATION 225 97.28 Very High Very High Very High
Pressure And Volume Under Development 20 96.96 Very High Very High Very High
Epilepsy 23 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Low concentrations (1 x 10(-9) and 1 x 10(-11) M) of morphine significantly (P < 0.05) augmented the production of CSFs, whereas high concentrations (1 x 10(-3) and 1 x 10(-5) M) inhibited CSF production.
Negative_regulation (inhibited) of Gene_expression (production) of CSF associated with morphine
1) Confidence 0.52 Published 2005 Journal Microbes Infect. Section Abstract Doc Link 15716055 Disease Relevance 0.16 Pain Relevance 0.68
Impact of GM-CSF use in HIV infected individuals
Negative_regulation (Impact) of Gene_expression (use) of GM-CSF associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.42 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 1.03 Pain Relevance 0
Mean HIV RNA levels declined in the GM-CSF group throughout the 6 months of the study.
Negative_regulation (declined) of Gene_expression (group) of GM-CSF associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.42 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 0.59 Pain Relevance 0
Stimulation of bone marrow-derived mouse neutrophils with LPS and/or GM-CSF
Negative_regulation (derived) of Gene_expression (/) of GM-CSF in neutrophils
4) Confidence 0.42 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526424 Disease Relevance 0 Pain Relevance 0.03
We have found that PGE2 and PGE1, but not PGF2 alpha, inhibit both proliferation and production of granulocyte-macrophage (GM)-CSF by murine TH clones stimulated with Ag or anti-CD3 antibody.
Negative_regulation (inhibit) of Gene_expression (production) of CSF in macrophage
5) Confidence 0.41 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2521509 Disease Relevance 0 Pain Relevance 0.04
USA 95 (1998) 3239] that in patients with severe depression there is a decrease in the CSF levels of 3alpha,5alpha-TH PROG, which is normalized by treatment with drugs (i.e. fluoxetine) that improve psychopathology.
Negative_regulation (decrease) of Gene_expression (levels) of CSF associated with depression and fluoxetine
6) Confidence 0.36 Published 2001 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 11744079 Disease Relevance 0.10 Pain Relevance 0.42
42 levels can identify PIB-positive individuals with highest possible sensitivity and specificity, the decreased CSF levels of A?
Negative_regulation (decreased) of Gene_expression (levels) of CSF
7) Confidence 0.34 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 0.94 Pain Relevance 0.04
Thus far, three CSF biomarkers, A?
Negative_regulation (three) of Gene_expression (biomarkers) of CSF in CSF
8) Confidence 0.34 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 0.87 Pain Relevance 0.04
In this study, at physiological concentrations, it profoundly inhibited CD40, CD80, CD86, and MHC class II expression on murine, GM-CSF + IL-4 stimulated, bone marrow-derived myeloid dendritic cells (DC).
Negative_regulation (inhibited) of Gene_expression (expression) of GM-CSF in myeloid dendritic cells
9) Confidence 0.23 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11390449 Disease Relevance 0.10 Pain Relevance 0.31
, inhibits osteoclast formation via increased production of GM-CSF by T cells and osteoblasts [20,21].
Negative_regulation (inhibits) of Gene_expression (production) of GM-CSF in osteoclast
10) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.63 Pain Relevance 0.29
can decrease the production of IL-6, IL-8, and GM-CSF by stimulated FLS from RA and OA patients.
Negative_regulation (decrease) of Gene_expression (production) of GM-CSF associated with rheumatoid arthritis and osteoarthritis
11) Confidence 0.23 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416442 Disease Relevance 1.07 Pain Relevance 0.50
subarachnoid spaces may occur for solute exchange, they may not contain CSF as
Neg (not) Negative_regulation (not) of Neg (not) Gene_expression (contain) of CSF
12) Confidence 0.12 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2643053 Disease Relevance 0.13 Pain Relevance 0.31
Decreased levels of brain and CSF GABA, increased levels of CSF and cortical glutamate, and decreased levels of PLP in the frontal cortex, have been described in this condition.
Negative_regulation (Decreased) of Gene_expression (levels) of CSF in frontal cortex associated with glutamate, gaba and urological neuroanatomy
13) Confidence 0.11 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 1.44 Pain Relevance 0.44
Primary PAP has also been associated with reduced detection of GM-CSF-R?
Negative_regulation (reduced) of Gene_expression (detection) of GM-CSF associated with pulmonary alveolar proteinosis
14) Confidence 0.10 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.90 Pain Relevance 0
Specifically, fucoidan treatment reduced the amounts of GM-CSF, IL-6, MCP-1, and RANTES (Fig. 6).
Negative_regulation (reduced) of Gene_expression (amounts) of GM-CSF
15) Confidence 0.09 Published 2010 Journal The Korean Journal of Hematology Section Body Doc Link PMC2983006 Disease Relevance 0.48 Pain Relevance 0.28
It has been suggested that 5-5HT2C receptors in choroid plexus may be tonically activated, due to CSF 5-HT concentrations near the EC50, thus tonically inhibiting CSF production.
Negative_regulation (inhibiting) of Gene_expression (production) of CSF in choroid plexus
16) Confidence 0.08 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC165579 Disease Relevance 0 Pain Relevance 0.07
Decreased levels of brain and CSF GABA, increased levels of CSF and cortical glutamate, and decreased levels of PLP in the frontal cortex, have been described in this condition.
Negative_regulation (decreased) of Gene_expression (levels) of CSF in frontal cortex associated with glutamate, gaba and urological neuroanatomy
17) Confidence 0.08 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 1.57 Pain Relevance 0.46
Anti TNF- however down-regulates the production of IL-1, IL-6, IL-8, and GM-CSF [28,29].
Negative_regulation (down) of Gene_expression (production) of GM-CSF
18) Confidence 0.06 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2860341 Disease Relevance 0.45 Pain Relevance 0.14
For example, upon intraventricular injection, 5-HT2C agonists decrease the production of CSF [44] and in primary cultures of choroid plexus, 5-HT agonists increase the expression of transferrin [45,46], an iron carrier protein which has trophic effects on the brain.
Negative_regulation (decrease) of Gene_expression (production) of CSF in choroid plexus associated with agonist
19) Confidence 0.06 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC165579 Disease Relevance 0 Pain Relevance 0.10
and also inhibits the production of GM-CSF, IFN-?
Negative_regulation (inhibits) of Gene_expression (production) of GM-CSF
20) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2838227 Disease Relevance 0.36 Pain Relevance 0.50

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