INT253940

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.82
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Gsk3a) kinase activity (Gsk3a)
Anatomy Link Frequency
skeletal muscle 1
adipose tissue 1
Gsk3a (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 18 100.00 Very High Very High Very High
Inflammation 26 98.68 Very High Very High Very High
cytokine 2 90.80 High High
alcohol 6 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 20 100.00 Very High Very High Very High
Obesity 22 99.04 Very High Very High Very High
INFLAMMATION 26 98.68 Very High Very High Very High
Metabolic Syndrome 106 84.64 Quite High
Cardiovascular Disease 42 53.12 Quite High
Hyperlipidemia 12 50.00 Quite Low
Diabetes Mellitus 18 37.32 Quite Low
Impaired Glucose Tolerance 4 34.16 Quite Low
Hypertension 4 33.16 Quite Low
Abdominal Obesity 2 32.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These adipokines lead to the systemic activation of several protein kinases involved in inflammatory signal transduction, including phosphoinositide-3 kinase (PI3K), glycogen synthase kinase (GSK-3) and PKC that singly or in concert cause insulin resistance in skeletal muscle and adipose tissue [22-24].
Gene_expression (resistance) of glycogen synthase kinase in skeletal muscle associated with kinase c, inflammation, obesity and insulin resistance
1) Confidence 0.08 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2588603 Disease Relevance 1.41 Pain Relevance 0.46
These adipokines lead to the systemic activation of several protein kinases involved in inflammatory signal transduction, including phosphoinositide-3 kinase (PI3K), glycogen synthase kinase (GSK-3) and PKC that singly or in concert cause insulin resistance in skeletal muscle and adipose tissue [22-24].
Gene_expression (resistance) of glycogen synthase kinase in adipose tissue associated with kinase c, inflammation, obesity and insulin resistance
2) Confidence 0.03 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2588603 Disease Relevance 1.41 Pain Relevance 0.46

General Comments

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