INT253941

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.59
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
liver 2
adipocytes 2
Adipoq (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 52 95.32 Very High Very High Very High
Kinase C 9 84.32 Quite High
agonist 73 62.08 Quite High
tolerance 6 45.60 Quite Low
cytokine 21 43.72 Quite Low
Potency 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 1 99.92 Very High Very High Very High
Obesity 458 99.76 Very High Very High Very High
Impaired Glucose Tolerance 8 99.56 Very High Very High Very High
Insulin Resistance 21 99.14 Very High Very High Very High
INFLAMMATION 54 95.32 Very High Very High Very High
Heart Rate Under Development 17 93.16 High High
Diabetes Mellitus 68 87.48 High High
Mycobacterium Infection 1 80.44 Quite High
Mycobacterial Infection 1 79.96 Quite High
Diarrhoea 1 79.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our laboratory has demonstrated that astragaloside II and isoastragaloside I from Radix Astragali alleviate insulin resistance, glucose intolerance and hyperglycemia by increasing the secretion of the insulin sensitizing hormone, adiponectin from adipocytes [17].
Positive_regulation (increasing) of Localization (secretion) of adiponectin in adipocytes associated with hyperglycemia, obesity, insulin resistance and impaired glucose tolerance
1) Confidence 0.24 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.93 Pain Relevance 0.03
target gene adiponectin (AdipoQ, probably from Kuppfer cells), and following overexpression of either PPAR?
Positive_regulation (gene) of Localization (target) of AdipoQ
2) Confidence 0.21 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.27 Pain Relevance 0.03
target gene adiponectin (AdipoQ, probably from Kuppfer cells), and following overexpression of either PPAR?
Positive_regulation (gene) of Localization (target) of adiponectin
3) Confidence 0.21 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.27 Pain Relevance 0.03
isoform the relative abundance of adiponectin was massively increased in relative terms (Figure 4), as expected based on prior reports using these liver samples [12, 13].
Positive_regulation (increased) of Localization (abundance) of adiponectin in liver
4) Confidence 0.21 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.27 Pain Relevance 0.03
-stimulated IL-6 secretion and improved adiponectin secretion.
Positive_regulation (improved) of Localization (secretion) of adiponectin
5) Confidence 0.07 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2588603 Disease Relevance 0.84 Pain Relevance 0.09

General Comments

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