INT253944

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.53
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Prkca, Ins1) mitochondrion (Prkca) endoplasmic reticulum (Prkca)
carbohydrate metabolic process (Ins1) enzyme binding (Prkca) protein complex (Prkca)
Prkca (Mus musculus)
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 9 100.00 Very High Very High Very High
Inflammation 13 83.28 Quite High
cytokine 1 69.44 Quite High
alcohol 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 10 100.00 Very High Very High Very High
Metabolic Syndrome 53 87.12 High High
INFLAMMATION 13 83.28 Quite High
Cardiovascular Disease 21 66.48 Quite High
Diabetes Mellitus 9 65.08 Quite High
Impaired Glucose Tolerance 2 61.92 Quite High
Hypertension 2 60.92 Quite High
Abdominal Obesity 1 60.36 Quite High
Dyslipidemia /

Combined Dyslipidemia

1 59.68 Quite High
Congenital Anomalies 4 58.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Metabolites of lipid metabolism such as diacylglycerol have been shown to directly induce insulin resistance by chronically activating protein kinase C (PKC).
Positive_regulation (activating) of PKC Positive_regulation (induce) of Gene_expression (resistance) of insulin associated with kinase c and insulin resistance
1) Confidence 0.01 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2588603 Disease Relevance 1.47 Pain Relevance 0.35

General Comments

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