INT25396

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 83
Total Number 87
Disease Relevance 46.81
Pain Relevance 14.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger2) plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
PGE2 8
macrophage 3
lung 3
cortex 3
oocytes 3
Ptger2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 937 100.00 Very High Very High Very High
Inflammatory response 145 100.00 Very High Very High Very High
Inflammatory mediators 132 100.00 Very High Very High Very High
cINOD 170 99.72 Very High Very High Very High
dexamethasone 13 99.68 Very High Very High Very High
Stimulus evoked pain 9 99.58 Very High Very High Very High
intrathecal 5 99.56 Very High Very High Very High
qutenza 200 99.54 Very High Very High Very High
Pain 101 99.54 Very High Very High Very High
Dynorphin 1 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1235 100.00 Very High Very High Very High
Pulmonary Disease 770 99.90 Very High Very High Very High
Cancer 749 99.86 Very High Very High Very High
Hemophilus Infection 623 99.84 Very High Very High Very High
Breast Cancer 206 99.76 Very High Very High Very High
Keloid Scars 152 99.62 Very High Very High Very High
Hypersensitivity 21 99.58 Very High Very High Very High
Obesity 734 99.52 Very High Very High Very High
Pain 114 99.24 Very High Very High Very High
Middle Cerebral Artery Infarction 41 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mouse oocytes, EP2 was localized throughout the cytoplasm while EP4 was primarily perinuclear in location.
Localization (localized) of EP2 in oocytes
1) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
Previously, Segi and colleagues used in situ hybridization to successfully localize mRNA for EP2 and EP4 (but not EP1 and EP3) to cumulus granulosa cells within mouse periovulatory follicles [9].
Neg (not) Localization (localize) of EP2 in follicles
2) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
To make such a conclusion, one needs to test whether selectively targeting EP2 would result in neuroprotection.
Localization (targeting) of EP2
3) Confidence 0.75 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.65 Pain Relevance 0.18
Primary antibodies for EP receptor localization were as described for monkey oocytes.
Localization (localization) of EP receptor in oocytes
4) Confidence 0.72 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
More recently, EP2, EP3 and EP4 mRNA and proteins were localized to mouse cumulus cells [10].
Localization (localized) of EP2 in cumulus cells
5) Confidence 0.72 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
Immunofluorescence and confocal microscopy were used to detect individual EP receptor proteins in monkey oocytes and determine the location of each EP receptor within the oocyte.
Spec (determine) Localization (location) of EP receptor in oocyte
6) Confidence 0.72 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
We also examined the localization of EP2, VEGF, Flt-1, and Flk-1 in the cochlea by immunohistochemistry.


Spec (examined) Localization (localization) of EP2 in cochlea
7) Confidence 0.57 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC2847564 Disease Relevance 0.22 Pain Relevance 0.19
This suggests the implication of EP2 and EP3 in the physiological functions of these regions of the brain.
Localization (implication) of EP2 in brain
8) Confidence 0.56 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.27
This involves interesting and efficient trafficking of EP2 and EP3, both of which are located at the postsynaptic sites in the neurons of the visual cortex.
Localization (located) of EP2 in cortex
9) Confidence 0.56 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.52
In cultures of neurons from the visual cortex, however, both EP2 and EP3 are highly colocalized with PSD-95 (EP2, 71%; EP3, 82%), but less colocalized with synaptophysin (EP2, 25%; EP3, 13%) (Akaneya and Tsumoto, 2006).
Localization (colocalized) of EP2 in neurons
10) Confidence 0.56 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.14
In cultures of neurons from the visual cortex, however, both EP2 and EP3 are highly colocalized with PSD-95 (EP2, 71%; EP3, 82%), but less colocalized with synaptophysin (EP2, 25%; EP3, 13%) (Akaneya and Tsumoto, 2006).
Localization (colocalized) of EP2 in cortex
11) Confidence 0.56 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.15
In cultures of neurons from the visual cortex, however, both EP2 and EP3 are highly colocalized with PSD-95 (EP2, 71%; EP3, 82%), but less colocalized with synaptophysin (EP2, 25%; EP3, 13%) (Akaneya and Tsumoto, 2006).
Localization (colocalized) of EP2 in neurons
12) Confidence 0.56 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.15
In cultures of neurons from the visual cortex, however, both EP2 and EP3 are highly colocalized with PSD-95 (EP2, 71%; EP3, 82%), but less colocalized with synaptophysin (EP2, 25%; EP3, 13%) (Akaneya and Tsumoto, 2006).
Localization (colocalized) of EP2 in cortex
13) Confidence 0.56 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.15
First, it has been reported that PGE2 increases excitatory postsynaptic potentials (EPSPs) in hippocampal slices and frequency, and that this action is via the EP2 which is located at the presynaptic sites (Sang et al. 2005; Zhu et al. 2005).
Localization (located) of EP2
14) Confidence 0.49 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.22
These data clearly show that TRPV1 currents evoked by any of three different stimuli (capsaicin, proton, or heat) are potentiated or sensitized by PGE2 through EP1 receptor activation.
Localization (potentiated) of PGE2 associated with qutenza
15) Confidence 0.43 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0 Pain Relevance 0.30
In this study, we assessed PGE2-stimulated cytochrome c release from the mitochondrial intermembrane space (19), a correlate of apoptosis.
Localization (release) of PGE2 associated with apoptosis
16) Confidence 0.42 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 2.09 Pain Relevance 0
EP2 receptor mediated cAMP release is augmented by PGF2?
Localization (release) of EP2
17) Confidence 0.39 Published 2010 Journal Cell Signal Section Title Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0.15
Cell-specific localisation of COX-1, COX-2, mPGES-1, EP1 and EP2 in the normal ovary
Localization (localisation) of EP2 in ovary
18) Confidence 0.39 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 1.02 Pain Relevance 0
Cell-specific localisation of COX-1, COX-2, mPGES-1, EP1 and EP2 in benign, borderline and malignant ovarian tumours
Localization (localisation) of EP2 associated with malignant neoplastic disease and ovarian cancer
19) Confidence 0.39 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.92 Pain Relevance 0
In the presence of PGE2 or PGI2, the temperature threshold for TRPV1 activation was reduced below 35°C, so that temperatures near body temperature are sufficient to activate TRPV1.
Localization (presence) of PGE2 in body
20) Confidence 0.37 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1074353 Disease Relevance 0.67 Pain Relevance 0.50

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