INT253970

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 12
Disease Relevance 8.16
Pain Relevance 4.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cd74) signal transduction (Cd74) Golgi apparatus (Cd74)
endoplasmic reticulum (Cd74) plasma membrane (Cd74) protein complex assembly (Cd74)
Anatomy Link Frequency
bladder 3
macrophages 2
monocytes 2
B lymphocytes 2
T lymphocytes 2
Cd74 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 536 98.80 Very High Very High Very High
cytokine 92 90.92 High High
chemokine 38 79.84 Quite High
Inflammatory response 40 71.44 Quite High
Crohn's disease 2 66.72 Quite High
Arthritis 4 66.04 Quite High
Stimulus evoked pain 4 59.36 Quite High
halothane 34 48.80 Quite Low
Lasting pain 2 47.32 Quite Low
dorsal root ganglion 8 33.32 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 588 98.80 Very High Very High Very High
Renal Disease 22 80.40 Quite High
Disease 66 66.72 Quite High
Injury 122 66.24 Quite High
Arthritis 4 66.04 Quite High
Cystitis 44 64.16 Quite High
Weight Loss 2 60.80 Quite High
Hypersensitivity 4 59.36 Quite High
Pain 6 58.68 Quite High
Infection 150 55.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We showed that MIF, CD44 and CD74 are all upregulated in the urothelium after experimental inflammation in rats [6], [17].
Positive_regulation (upregulated) of CD74 associated with inflammation
1) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.94 Pain Relevance 0.46
CD74 bladder immunostaining, and total amount of bladder CD74 protein and mRNA, are increased in an acute model of bladder inflammation [33].
Positive_regulation (increased) of CD74 in bladder associated with inflammation
2) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.51 Pain Relevance 0.26
CD74 bladder immunostaining, and total amount of bladder CD74 protein and mRNA, are increased in an acute model of bladder inflammation [33].
Positive_regulation (increased) of CD74 protein in bladder associated with inflammation
3) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.50 Pain Relevance 0.25
The high up-regulation of CD74, HLA-DQB, and THY1 (Table 1, Figure 1c) suggests infiltration of inflammation-related cells, such as T lymphocytes and B lymphocytes, monocytes, and macrophages.
Positive_regulation (regulation) of CD74 in B lymphocytes associated with inflammation
4) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.68 Pain Relevance 0.35
The high up-regulation of CD74, HLA-DQB, and THY1 (Table 1, Figure 1c) suggests infiltration of inflammation-related cells, such as T lymphocytes and B lymphocytes, monocytes, and macrophages.
Positive_regulation (up) of CD74 in B lymphocytes associated with inflammation
5) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.73 Pain Relevance 0.35
Examining the differences between MIF activation of CXCR4 receptors versus MIF activation of CD74 receptors then might provide insights into the actual mechanism for MIF-mediated effects in the bladder and possibly other sites.


Positive_regulation (activation) of CD74 in bladder
6) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.55 Pain Relevance 0.32
The high up-regulation of CD74, HLA-DQB, and THY1 (Table 1, Figure 1c) suggests infiltration of inflammation-related cells, such as T lymphocytes and B lymphocytes, monocytes, and macrophages.
Positive_regulation (up) of CD74 in monocytes associated with inflammation
7) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.73 Pain Relevance 0.35
The high up-regulation of CD74, HLA-DQB, and THY1 (Table 1, Figure 1c) suggests infiltration of inflammation-related cells, such as T lymphocytes and B lymphocytes, monocytes, and macrophages.
Positive_regulation (regulation) of CD74 in monocytes associated with inflammation
8) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.68 Pain Relevance 0.35
The high up-regulation of CD74, HLA-DQB, and THY1 (Table 1, Figure 1c) suggests infiltration of inflammation-related cells, such as T lymphocytes and B lymphocytes, monocytes, and macrophages.
Positive_regulation (up) of CD74 in T lymphocytes associated with inflammation
9) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.73 Pain Relevance 0.35
The high up-regulation of CD74, HLA-DQB, and THY1 (Table 1, Figure 1c) suggests infiltration of inflammation-related cells, such as T lymphocytes and B lymphocytes, monocytes, and macrophages.
Positive_regulation (regulation) of CD74 in macrophages associated with inflammation
10) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.68 Pain Relevance 0.35
The high up-regulation of CD74, HLA-DQB, and THY1 (Table 1, Figure 1c) suggests infiltration of inflammation-related cells, such as T lymphocytes and B lymphocytes, monocytes, and macrophages.
Positive_regulation (regulation) of CD74 in T lymphocytes associated with inflammation
11) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.68 Pain Relevance 0.35
The high up-regulation of CD74, HLA-DQB, and THY1 (Table 1, Figure 1c) suggests infiltration of inflammation-related cells, such as T lymphocytes and B lymphocytes, monocytes, and macrophages.
Positive_regulation (up) of CD74 in macrophages associated with inflammation
12) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.73 Pain Relevance 0.35

General Comments

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