INT253971

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Context Info
Confidence 0.98
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.62
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4) plasma membrane (Cxcr4)
signal transducer activity (Cxcr4)
Anatomy Link Frequency
neurons 1
Cxcr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 66 66.52 Quite High
chemokine 38 59.48 Quite High
cytokine 12 5.00 Very Low Very Low Very Low
dorsal root ganglion 8 5.00 Very Low Very Low Very Low
halothane 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Stimulus evoked pain 4 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bladder Cancer 6 78.48 Quite High
Hyperplasia 4 67.60 Quite High
INFLAMMATION 68 66.52 Quite High
Cancer 2 55.60 Quite High
Cystitis 34 50.00 Quite Low
Stress Incontinence 2 26.40 Quite Low
Injury 12 5.00 Very Low Very Low Very Low
Body Weight 10 5.00 Very Low Very Low Very Low
Ganglion Cysts 8 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A similar discrepancy between CXCR4 mRNA expression and protein levels has been reported in the rat neurons and shown to reflect activation, increased internalization and degradation of CXCR4 receptors [27] .
Protein_catabolism (degradation) of CXCR4 in neurons
1) Confidence 0.98 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.28 Pain Relevance 0.06
Such activation, internalization and degradation of CXCR4 receptors may also account for the patchy CXCR4 immunostaining in the urothelium (especially with immunostaining in the apical surface of superficial cells) and may represent focal areas of CYP-induced CXCR4 response.
Protein_catabolism (degradation) of CXCR4
2) Confidence 0.64 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.34 Pain Relevance 0.06

General Comments

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