INT253972

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.22
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
neurons 2
Cxcl12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 88 99.28 Very High Very High Very High
Lasting pain 5 98.68 Very High Very High Very High
Eae 4 96.72 Very High Very High Very High
chemokine 123 95.96 Very High Very High Very High
Stimulus evoked pain 2 93.36 High High
Neuropathic pain 24 91.24 High High
Peripheral nerve injury 6 87.72 High High
substance P 1 80.84 Quite High
antagonist 36 69.52 Quite High
nociceptor 10 69.08 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 10 100.00 Very High Very High Very High
Cystitis 17 99.84 Very High Very High Very High
Ganglion Cysts 88 99.28 Very High Very High Very High
Pain 13 98.68 Very High Very High Very High
Neuropathic Pain 33 96.44 Very High Very High Very High
Injury 72 96.04 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 42 92.28 High High
Syndrome 6 91.64 High High
Nervous System Injury 16 87.72 High High
Rheumatoid Arthritis 20 83.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In CYP-induced cystitis, then, activation of CXCR4 receptors, either by its recognized ligand SDF-1 (upregulated as a result of CYP) or due to interaction with MIF (also upregulated as a result of CYP and present in greater quantities than SDF-1) may in fact be contributing to pain hypersensitivity.
Spec (may) Positive_regulation (activation) of Positive_regulation (upregulated) of SDF-1 associated with hypersensitivity, stimulus evoked pain and cystitis
1) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.29 Pain Relevance 0.87
It was previously shown that NRTI treatment alone resulted in both increased mechanical hypersensitivity and upregulation of CXCR4/SDF1 signaling in the DRG [22].
Positive_regulation (increased) of Positive_regulation (upregulation) of SDF1 associated with dorsal root ganglion and hypersensitivity
2) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.08 Pain Relevance 0.36
We have previously shown that ddC treatment alone resulted in the upregulation of CXCR4 and SDF1 mostly in glia, but also in some neurons of the DRG.
Positive_regulation (resulted) of Positive_regulation (upregulation) of SDF1 in neurons associated with dorsal root ganglion
3) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.85 Pain Relevance 0.48

General Comments

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