INT253974

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 12.26
Pain Relevance 5.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4) plasma membrane (Cxcr4)
signal transducer activity (Cxcr4)
Anatomy Link Frequency
bladder 13
Macrophage 1
neurons 1
bone marrow 1
T cells 1
Cxcr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 523 100.00 Very High Very High Very High
Lasting pain 25 99.40 Very High Very High Very High
Inflammation 652 99.28 Very High Very High Very High
cytokine 137 99.20 Very High Very High Very High
antagonist 63 95.04 Very High Very High Very High
dorsal root ganglion 202 88.76 High High
Neuropathic pain 36 87.36 High High
Pain 20 85.92 High High
Stimulus evoked pain 38 84.08 Quite High
Peripheral nerve injury 9 81.76 Quite High
Disease Link Frequency Relevance Heat
Cystitis 323 99.84 Very High Very High Very High
Bladder Cancer 57 99.76 Very High Very High Very High
Pain 74 99.40 Very High Very High Very High
INFLAMMATION 683 99.28 Very High Very High Very High
Colon Cancer 19 97.36 Very High Very High Very High
Injury 218 96.92 Very High Very High Very High
Inflammatory Bowel Disease 19 96.08 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 63 93.96 High High
Atherosclerosis 35 88.80 High High
Ganglion Cysts 202 88.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we hypothesized that CXCR4-MIF complex formation may also occur in the bladder (as described occurring in vitro [18]).
CXCR4 Binding (formation) of in bladder
1) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.54 Pain Relevance 0.29
Using dual immunohistochemistry we show that MIF and CXCR4 are colocalized within the same cells in the urothelium and co-immunoprecipitation studies demonstrate MIF-CXCR4 associations in the bladder.
CXCR4 Binding (associations) of in bladder
2) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.73 Pain Relevance 0.12
Although chemokines typically display a high degree of receptor promiscuity, CXCR4 was (until recently) thought to bind only to SDF-1 [19].
CXCR4 Binding (bind) of associated with chemokine
3) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.50 Pain Relevance 0.26
Tissue sections were analyzed for the presence of TRPV1 or IB4-binding neurons and either CXCR4 or CCR2.
CXCR4 Spec (analyzed) Binding (binding) of in neurons
4) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.17 Pain Relevance 0.08
Co-immunoprecipitation studies with CXCR4 antisera to “pull-down” CXCR4 protein complexes in bladder homogenates were followed by MIF Western-blotting in order to detect CXCR4-MIF complexes in bladder homogenates.
CXCR4 protein Binding (complexes) of in bladder
5) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
The exact role of CXCR4 and MIF-CXCR4 associations in the bladder was not addressed in the present study and remains to be investigated.
CXCR4 Binding (associations) of in bladder
6) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.56 Pain Relevance 0.26
The object of the present study was to determine if there was an association between MIF and CXCR4 receptors in the bladder.
CXCR4 Binding (association) of in bladder
7) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.70 Pain Relevance 0.28
Immunoprecipitation demonstrated an association between CXCR4 and MIF in the bladder.
CXCR4 Binding (association) of in bladder
8) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.56 Pain Relevance 0.46
Therefore, we examined: 1) location of cytokine receptor CXCR4 in the rat bladder; 2) baseline bladder levels of SDF-1 (cognate ligand for CXCR4) and changes in response to a chemically-induced (cyclophosphamide; CYP) model of bladder inflammation; 3) CXCR4 expression changes after CYP-induced cystitis and 4) association between CXCR4 and MIF in the bladder before and after CYP-induced cystitis.
CXCR4 Binding (association) of in bladder associated with inflammation, cystitis and cytokine
9) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.81 Pain Relevance 0.21
CXCR4 is expressed by normal urothelium and may be associated with bladder cancer [20], [21].
CXCR4 Binding (associated) of in bladder associated with bladder cancer
10) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.50 Pain Relevance 0.27
Recently, however, a novel functional association between MIF and chemokine receptors CXCR2 and CXCR4 was described in T cells in vitro [18].
CXCR4 Binding (association) of in T cells associated with chemokine
11) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.81 Pain Relevance 0.44
The results from the present study indicate that MIF, by associating with CXCR4 receptors in the bladder (presumably urothelial in origin), may be competing with SDF-1 at CXCR4 receptors to participate in epithelial repair following injury.
CXCR4 Binding (associating) of in bladder associated with injury
12) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.15 Pain Relevance 0.62
The exact role of CXCR4 and MIF-CXCR4 associations in the bladder was not addressed in the present study and remains to be investigated.
CXCR4 Binding (associations) of in bladder
13) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.56 Pain Relevance 0.27
These data demonstrate CXCR4-MIF associations occur in vivo in rat bladder and increase in experimental cystitis.
CXCR4 Binding (associations) of in bladder associated with cystitis
14) Confidence 0.35 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2588654 Disease Relevance 0.40 Pain Relevance 0.15
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine involved in cystitis and a non-cognate ligand of the chemokine receptor CXCR4 in vitro.
CXCR4 Binding (ligand) of in Macrophage associated with chemokine, inflammation, cystitis and cytokine
15) Confidence 0.35 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2588654 Disease Relevance 0.45 Pain Relevance 0.22
We studied whether CXCR4-MIF associations occur in rat bladder and the effect of experimental cystitis.


CXCR4 Binding (associations) of in bladder associated with cystitis
16) Confidence 0.35 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2588654 Disease Relevance 0.45 Pain Relevance 0.22
However, recent in vitro evidence showed that CXCR4 is also capable of binding MIF [18].
CXCR4 Binding (binding) of
17) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.33 Pain Relevance 0.29
Cyclophosphamide upregulated bladder CXCR4 expression: MIF-CXCR4 associations in the bladder
CXCR4 Binding (associations) of in bladder
18) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
Until recently, CXCR4 was considered to bind exclusively to SDF-1 [19].
CXCR4 Binding (bind) of
19) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.33 Pain Relevance 0.30
MIF, however, competed with the recognized ligand for CXCR4 (SDF-1/CXCL12) for binding to CXCR4 [18].
CXCR4 Binding (binding) of
20) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.49 Pain Relevance 0.27

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