INT253976

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.19
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4) plasma membrane (Cxcr4)
signal transducer activity (Cxcr4)
Anatomy Link Frequency
bladder 4
Cxcr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 57 100.00 Very High Very High Very High
Inflammation 99 99.98 Very High Very High Very High
cytokine 18 93.36 High High
Stimulus evoked pain 6 84.52 Quite High
Lasting pain 3 72.48 Quite High
dorsal root ganglion 12 58.48 Quite High
substance P 3 54.64 Quite High
halothane 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 102 99.98 Very High Very High Very High
Injury 18 99.46 Very High Very High Very High
Cystitis 51 89.32 High High
Hypersensitivity 6 84.52 Quite High
Pain 9 83.84 Quite High
Hyperplasia 6 80.52 Quite High
Stress Incontinence 3 62.04 Quite High
Neuropathic Pain 3 60.80 Quite High
Ganglion Cysts 12 58.48 Quite High
Bladder Cancer 9 47.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, the chemokine receptor CXCR4 is constitutively expressed in rat urothelium (in basal and intermediate cells) while CYP-induced bladder inflammation resulted in upregulation of CXCR4 and immunostaining of superficial cells (previously devoid of CXCR4).
Positive_regulation (resulted) of Positive_regulation (upregulation) of CXCR4 in bladder associated with chemokine and inflammation
1) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.74 Pain Relevance 0.63
CYP treatment although producing CXCR4 mRNA upregulation (a novel finding) did not result in increased CXCR4 protein levels, and scoring of CXCR4 immunostaining actually showed a decrease in staining intensity following CYP treatment.
Neg (not) Positive_regulation (result) of Neg (not) Positive_regulation (increased) of CXCR4 protein
2) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.16 Pain Relevance 0.08
Thus our findings indicate that bladder injury produced by CYP-treatment results in mRNA upregulation of the chemokine receptor CXCR4 and increased protein levels of its cognate ligand, SDF-1.
Positive_regulation (results) of Positive_regulation (upregulation) of CXCR4 in bladder associated with chemokine and injury
3) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.30 Pain Relevance 0.25

General Comments

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