INT253978

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.61
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4) plasma membrane (Cxcr4)
signal transducer activity (Cxcr4)
Anatomy Link Frequency
neutrophils 1
Cxcr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 1 86.24 High High
cva 4 77.52 Quite High
cytokine 11 73.24 Quite High
ischemia 8 51.80 Quite High
Inflammation 44 33.76 Quite Low
chemokine 21 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
dorsal root ganglion 4 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 35 97.12 Very High Very High Very High
Coronary Stenosis 1 94.92 High High
Hemorrhage 3 77.52 Quite High
Atherosclerotic Plaque 1 69.52 Quite High
Cv Unclassified Under Development 9 51.80 Quite High
Cystitis 17 50.00 Quite Low
Cardiovascular Disease 7 50.00 Quite Low
Increased Venous Pressure Under Development 2 40.32 Quite Low
INFLAMMATION 49 33.76 Quite Low
Hyperplasia 3 29.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
0.0011), thus confirming redistribution of CXCR4 immunostaining.
Negative_regulation (redistribution) of CXCR4
1) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
In the apoE-/- mice model, disruption of the SDF/CXCR4 by the drug AMD3100 increased bone marrow production, blood levels and atherosclerotic infiltration of neutrophils, an event which was able to be prevented by anti-neutrophil antibody injection (Zernecke et al 2008).


Negative_regulation (disruption) of CXCR4 in neutrophils associated with atherosclerosis
2) Confidence 0.11 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.61 Pain Relevance 0.18

General Comments

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