INT253982

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.85
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) plasma membrane (Cxcl12)
Cxcl12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Lasting pain 3 98.68 Very High Very High Very High
Stimulus evoked pain 6 96.12 Very High Very High Very High
chemokine 57 95.96 Very High Very High Very High
dorsal root ganglion 12 84.68 Quite High
substance P 3 80.84 Quite High
Inflammation 99 60.64 Quite High
cytokine 18 5.00 Very Low Very Low Very Low
halothane 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystitis 51 99.84 Very High Very High Very High
Pain 9 98.68 Very High Very High Very High
Hypersensitivity 6 95.92 Very High Very High Very High
Neuropathic Pain 3 87.00 High High
Ganglion Cysts 12 84.68 Quite High
Injury 18 67.64 Quite High
INFLAMMATION 102 60.64 Quite High
Colon Cancer 3 57.72 Quite High
Inflammatory Bowel Disease 3 56.44 Quite High
Body Weight 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In CYP-induced cystitis, then, activation of CXCR4 receptors, either by its recognized ligand SDF-1 (upregulated as a result of CYP) or due to interaction with MIF (also upregulated as a result of CYP and present in greater quantities than SDF-1) may in fact be contributing to pain hypersensitivity.
Spec (may) Positive_regulation (activation) of SDF-1 Binding (recognized) of associated with hypersensitivity, stimulus evoked pain and cystitis
1) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.29 Pain Relevance 0.86
In CYP-induced cystitis, then, activation of CXCR4 receptors, either by its recognized ligand SDF-1 (upregulated as a result of CYP) or due to interaction with MIF (also upregulated as a result of CYP and present in greater quantities than SDF-1) may in fact be contributing to pain hypersensitivity.
Positive_regulation (upregulated) of SDF-1 Binding (recognized) of associated with hypersensitivity, stimulus evoked pain and cystitis
2) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.27 Pain Relevance 0.85
In CYP-induced cystitis, then, activation of CXCR4 receptors, either by its recognized ligand SDF-1 (upregulated as a result of CYP) or due to interaction with MIF (also upregulated as a result of CYP and present in greater quantities than SDF-1) may in fact be contributing to pain hypersensitivity.
Positive_regulation (upregulated) of SDF-1 Binding (recognized) of associated with hypersensitivity, stimulus evoked pain and cystitis
3) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.29 Pain Relevance 0.89

General Comments

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