INT253983

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.33
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
bladder 2
sensory neurons 1
Cxcl12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 237 99.98 Very High Very High Very High
Lasting pain 11 98.64 Very High Very High Very High
Inflammation 235 98.46 Very High Very High Very High
cytokine 48 98.00 Very High Very High Very High
peripheral neuropathy 10 93.40 High High
Stimulus evoked pain 14 92.84 High High
Neuropathic pain 24 91.36 High High
antagonist 36 86.32 High High
Peripheral nerve injury 6 85.36 High High
dorsal root ganglion 112 82.88 Quite High
Disease Link Frequency Relevance Heat
Cystitis 119 98.94 Very High Very High Very High
Pain 31 98.64 Very High Very High Very High
INFLAMMATION 246 98.46 Very High Very High Very High
Injury 108 97.36 Very High Very High Very High
Peripheral Neuropathy 10 93.40 High High
Hypersensitivity 22 92.64 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 42 92.44 High High
Bladder Cancer 21 92.32 High High
Neuropathic Pain 39 91.36 High High
Nervous System Injury 16 84.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although chemokines typically display a high degree of receptor promiscuity, CXCR4 was (until recently) thought to bind only to SDF-1 [19].
SDF-1 Binding (bind) of associated with chemokine
1) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.49 Pain Relevance 0.26
In CYP-induced cystitis, then, activation of CXCR4 receptors, either by its recognized ligand SDF-1 (upregulated as a result of CYP) or due to interaction with MIF (also upregulated as a result of CYP and present in greater quantities than SDF-1) may in fact be contributing to pain hypersensitivity.
SDF-1 Binding (recognized) of associated with hypersensitivity, stimulus evoked pain and cystitis
2) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.27 Pain Relevance 0.85
Its cognate chemokine ligand, SDF-1 is also upregulated by CYP-treatment.
SDF-1 Binding (ligand) of associated with chemokine
3) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.65 Pain Relevance 0.55
Thus our findings indicate that bladder injury produced by CYP-treatment results in mRNA upregulation of the chemokine receptor CXCR4 and increased protein levels of its cognate ligand, SDF-1.
SDF-1 Binding (ligand) of in bladder associated with chemokine and injury
4) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.30 Pain Relevance 0.26
MIF, however, competed with the recognized ligand for CXCR4 (SDF-1/CXCL12) for binding to CXCR4 [18].
CXCL12 Binding (recognized) of
5) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.49 Pain Relevance 0.28
Until recently, CXCR4 was considered to bind exclusively to SDF-1 [19].
SDF-1 Binding (bind) of
6) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.33 Pain Relevance 0.30
Therefore, although, not directly tested in this study, our results suggest that MIF in the bladder may participate in bladder inflammation either through binding to CXCR4 in the urothelium (formerly thought to only bind SDF-1 but recently shown to also bind MIF [18]) or to CD74 (recognized binding protein for MIF which is upregulated in bladder inflammation [6]) to activate signal transduction pathways that result in the production of other inflammatory cytokines.
SDF-1 Binding (bind) of in bladder associated with inflammation and cytokine
7) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.48 Pain Relevance 0.38
The combination of perineural gp120/hCD4 treatment with ddC produced increased neuronal expression of both CXCR4 and CCR2 receptors together with their respective ligands, SDF1 and MCP1 in rather distinct subpopulations of sensory neurons.
SDF1 Binding (ligands) of in sensory neurons
8) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.39 Pain Relevance 0.37
Several studies on the mechanisms underlying chronic pain have focused on the CCR2 and CXCR4 receptors, and their respective ligands, MCP1 and SDF1.
SDF1 Binding (ligands) of associated with lasting pain
9) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.92 Pain Relevance 0.47

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