INT253988

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 6.57
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cd74, Mif) isomerase activity (Mif) aging (Mif)
Golgi apparatus (Cd74) endoplasmic reticulum (Cd74) protein complex assembly (Cd74)
Anatomy Link Frequency
bladder 1
Cd74 (Rattus norvegicus)
Mif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 198 100.00 Very High Very High Very High
cytokine 36 92.80 High High
Crohn's disease 6 85.28 High High
Arthritis 12 84.60 Quite High
chemokine 114 73.60 Quite High
Inflammatory stimuli 6 46.96 Quite Low
Inflammatory mediators 6 46.48 Quite Low
dorsal root ganglion 24 5.00 Very Low Very Low Very Low
halothane 12 5.00 Very Low Very Low Very Low
Stimulus evoked pain 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 204 100.00 Very High Very High Very High
Disease 18 85.28 High High
Arthritis 12 84.60 Quite High
Injury 36 76.88 Quite High
Urinary Tract Infection 6 71.08 Quite High
Cystitis 102 69.36 Quite High
Sepsis 6 55.00 Quite High
Adult Respiratory Distress Syndrome 6 54.56 Quite High
Renal Disease 6 53.80 Quite High
Bladder Cancer 18 21.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Until recently, complex formation between MIF and cell-surface CD74 was the only described mechanism for MIF-receptor interaction [15] .
CD74 Binding (interaction) of MIF-receptor
1) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.34 Pain Relevance 0.43
Therefore, although, not directly tested in this study, our results suggest that MIF in the bladder may participate in bladder inflammation either through binding to CXCR4 in the urothelium (formerly thought to only bind SDF-1 but recently shown to also bind MIF [18]) or to CD74 (recognized binding protein for MIF which is upregulated in bladder inflammation [6]) to activate signal transduction pathways that result in the production of other inflammatory cytokines.
CD74 Binding (binding) of MIF in bladder associated with inflammation and cytokine
2) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.50 Pain Relevance 0.40
Until recently, complex formation between MIF and cell-surface CD74 was the only described mechanism for MIF-receptor interaction [15] .
CD74 Binding (interaction) of MIF-receptor
3) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.34 Pain Relevance 0.43
MIF binds to cell-surface CD74 [15] and the MIF-CD74 complex then activates signal transduction by binding to another cell-surface receptor, CD44 [14].
CD74 Binding (complex) of MIF-CD74
4) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.01 Pain Relevance 0.42
Until recently, complex formation between MIF and cell-surface CD74 was the only described mechanism for MIF-receptor interaction [15] .
CD74 Binding (formation) of MIF
5) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.36 Pain Relevance 0.43
MIF binds to cell-surface CD74 [15] and the MIF-CD74 complex then activates signal transduction by binding to another cell-surface receptor, CD44 [14].
CD74 Binding (binds) of MIF
6) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.01 Pain Relevance 0.42

General Comments

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