INT254

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Context Info
Confidence 0.60
First Reported 1977
Last Reported 2004
Negated 2
Speculated 3
Reported most in Abstract
Documents 30
Total Number 34
Disease Relevance 5.17
Pain Relevance 11.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GHRH) extracellular region (GHRH) cell-cell signaling (GHRH)
Anatomy Link Frequency
blood 2
plasma 2
neurons 2
pituitary 2
GHRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 72 100.00 Very High Very High Very High
narcan 34 100.00 Very High Very High Very High
opiate 12 100.00 Very High Very High Very High
antagonist 11 100.00 Very High Very High Very High
agonist 8 100.00 Very High Very High Very High
Catecholamine 6 100.00 Very High Very High Very High
Morphine 6 100.00 Very High Very High Very High
Opioid 9 99.98 Very High Very High Very High
Pain threshold 5 99.52 Very High Very High Very High
Enkephalin 6 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoglycemia 11 100.00 Very High Very High Very High
Obesity 14 99.84 Very High Very High Very High
Uremia 5 99.84 Very High Very High Very High
Aging 2 99.68 Very High Very High Very High
Alcohol Addiction 3 99.66 Very High Very High Very High
Pain 7 99.52 Very High Very High Very High
Pituitary Cancer 2 98.88 Very High Very High Very High
Renal Failure 11 98.76 Very High Very High Very High
Chronic Renal Failure 1 98.48 Very High Very High Very High
Hypotension 1 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the control of the GHRH secretion by peptidergic hypothalamic neurons occurs through four principal monoaminergic systems such as dopaminergic, noradrenergic, adrenergic and serotoninergic ones, and also by cholinergic fibers and by endogenous opiates, all acting to cause the release, into the hypothalamo-hypophyseal portal circulation, of GHRH.
Regulation (control) of Localization (secretion) of GHRH in neurons associated with opiate and monoamine
1) Confidence 0.60 Published 1989 Journal Minerva Med. Section Abstract Doc Link 2566960 Disease Relevance 0.19 Pain Relevance 0.14
The effect of cyproheptadine on growth hormone (GH) secretion and dental pain threshold elevation during physical exercise was studied in healthy human subjects.
Regulation (effect) of Localization (secretion) of growth hormone associated with pain threshold
2) Confidence 0.60 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 3774237 Disease Relevance 0.40 Pain Relevance 0.46
Effect of clonidine on growth hormone release in psychiatric patients and controls.
Regulation (Effect) of Localization (release) of growth hormone associated with clonidine
3) Confidence 0.58 Published 1980 Journal Psychiatry Res Section Title Doc Link 6251501 Disease Relevance 0.15 Pain Relevance 0.56
Human growth hormone release is affected by a variety of pharmacological and physiological stimuli.
Regulation (affected) of Localization (release) of growth hormone
4) Confidence 0.52 Published 1990 Journal Acta Endocrinol. Section Abstract Doc Link 2106191 Disease Relevance 0.17 Pain Relevance 0.36
Modulation by glucocorticoids of growth hormone secretion in patients with different pituitary tumors.
Regulation (Modulation) of Localization (secretion) of growth hormone in pituitary associated with pituitary cancer
5) Confidence 0.45 Published 1993 Journal Neuroendocrinology Section Title Doc Link 8284031 Disease Relevance 0.18 Pain Relevance 0.18
Long-term effects of recombinant human erythropoietin therapy on growth hormone secretion in uremic patients undergoing peritoneal dialysis.
Regulation (effects) of Localization (secretion) of growth hormone associated with renal failure and uremia
6) Confidence 0.44 Published 1999 Journal Metab. Clin. Exp. Section Title Doc Link 10024084 Disease Relevance 1.02 Pain Relevance 0.07
These data suggest that exogenous opioids act as a site downstream to the alpha 1-adrenoceptor input to CRF release; it appears that opioids modulate adrenocorticotrophic hormone release in man at a minimum of two distinct and separate sites.
Regulation (modulate) of Localization (release) of adrenocorticotrophic hormone associated with opioid
7) Confidence 0.44 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1646411 Disease Relevance 0 Pain Relevance 0.60
Several alterations of growth hormone (GH) secretion have been described in patients with chronic renal failure.
Regulation (alterations) of Localization (secretion) of growth hormone associated with chronic renal failure
8) Confidence 0.43 Published 1992 Journal Adv Perit Dial Section Abstract Doc Link 1361819 Disease Relevance 0.50 Pain Relevance 0
Athletes have taken arginine for three main reasons: 1) its role in the secretion of endogenous growth hormone [4]; 2) its involvement in the synthesis of creatine; 3) its role in augmenting nitric oxide.
Regulation (role) of Localization (secretion) of growth hormone
9) Confidence 0.42 Published 2004 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129157 Disease Relevance 0 Pain Relevance 0.07
We therefore investigated the effect of the opiate antagonist naloxone on the stimulated growth hormone and prolactin secretions in a controlled double-blind study in obese patients.
Spec (investigated) Regulation (effect) of Localization (secretions) of growth hormone associated with antagonist, obesity, narcan and opiate
10) Confidence 0.39 Published 1987 Journal J. Endocrinol. Invest. Section Abstract Doc Link 3035002 Disease Relevance 0.36 Pain Relevance 0.47
The effect of naloxone on growth hormone and prolactin secretions in obese humans can thus be regarded as a partial normalization.
Regulation (effect) of Localization (secretions) of growth hormone associated with obesity and narcan
11) Confidence 0.39 Published 1987 Journal J. Endocrinol. Invest. Section Abstract Doc Link 3035002 Disease Relevance 0.39 Pain Relevance 0.51
To assess the possible influence of alcoholism on serotonergic control of growth hormone (GH) secretion, 6 mg of the 5-HT1D serotonergic receptor agonist, sumatriptan, was injected subcutaneously in a group of nine normal controls (aged 32 to 49 years) and in nine age-matched nondepressed male alcoholic subjects after 10 to 25 days of abstinence from alcohol.
Spec (possible) Regulation (control) of Localization (secretion) of hormone associated with sumatriptan, alcohol addiction, agonist and alcohol
12) Confidence 0.39 Published 1995 Journal Metab. Clin. Exp. Section Abstract Doc Link 8786727 Disease Relevance 0.25 Pain Relevance 0.30
Differential effects of deltorphin on arginine and galanin-induced growth hormone secretion in healthy man.
Regulation (effects) of Localization (secretion) of growth hormone
13) Confidence 0.39 Published 1995 Journal Regul. Pept. Section Title Doc Link 8570858 Disease Relevance 0 Pain Relevance 0.21
The effect of BS 100-141, N-amidino 2-(2.6 dichlorophenyl) acetamide hydrochloride, a new drug with central alpha-adrenoceptor activity, on growth hormone (GH) secretion was investigated in 24 young, healthy volunteers.
Spec (investigated) Regulation (effect) of Localization (secretion) of growth hormone
14) Confidence 0.34 Published 1977 Journal Metab. Clin. Exp. Section Abstract Doc Link 20551 Disease Relevance 0 Pain Relevance 0.14
Cholinergic receptor control mechanisms for L-dopa, apomorphine, and clonidine-induced growth hormone secretion in man.
Regulation (control) of Localization (secretion) of growth hormone associated with clonidine
15) Confidence 0.28 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 6688812 Disease Relevance 0 Pain Relevance 0.32
The effects of methysergide (1 mg, p.o.), clonidine (50 micrograms, i.m.) and methysergide plus clonidine on growth hormone (GH) and prolactin (PRL) secretion in 8 normal male volunteers have been studied.
Regulation (effects) of Localization (secretion) of growth hormone associated with clonidine
16) Confidence 0.28 Published 1981 Journal Neurosci. Lett. Section Abstract Doc Link 7219880 Disease Relevance 0 Pain Relevance 0.55
Effects of the interaction between methysergide and clonidine on growth hormone and prolactin secretion in normal man.
Regulation (Effects) of Localization (secretion) of growth hormone associated with clonidine
17) Confidence 0.28 Published 1981 Journal Neurosci. Lett. Section Title Doc Link 7219880 Disease Relevance 0 Pain Relevance 0.58
The stimulatory effect of clonidine on GH secretion has been suggested to depend on an enhancement of hypothalamic GH-releasing hormone (GHRH) release.
Regulation (depend) of Localization (release) of GHRH associated with clonidine
18) Confidence 0.27 Published 1991 Journal Horm. Res. Section Abstract Doc Link 1823078 Disease Relevance 0.59 Pain Relevance 0.33
Effects of alpha- and beta-adrenergic agonists and antagonists on growth hormone secretion in man.
Regulation (Effects) of Localization (secretion) of growth hormone associated with antagonist and agonist
19) Confidence 0.23 Published 1990 Journal Endocrinol. Exp. Section Title Doc Link 1972919 Disease Relevance 0 Pain Relevance 0.74
Effect of exogenous growth hormone administration on endogenous growth hormone secretion induced by a met-enkephalin analog.
Regulation (Effect) of Localization (secretion) of endogenous growth hormone associated with enkephalin
20) Confidence 0.23 Published 1996 Journal Eur. J. Endocrinol. Section Title Doc Link 8590960 Disease Relevance 0 Pain Relevance 0.28

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