INT2540

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2010
Negated 18
Speculated 11
Reported most in Abstract
Documents 538
Total Number 550
Disease Relevance 172.11
Pain Relevance 384.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
nerve 33
dorsal horn 22
neurons 19
dorsal root ganglia 15
sensory nerves 14
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 3777 100.00 Very High Very High Very High
qutenza 2331 100.00 Very High Very High Very High
substance P 831 100.00 Very High Very High Very High
Pain 790 100.00 Very High Very High Very High
Neuropeptide 495 100.00 Very High Very High Very High
antagonist 470 100.00 Very High Very High Very High
Spinal cord 356 100.00 Very High Very High Very High
Glutamate 293 100.00 Very High Very High Very High
headache 243 100.00 Very High Very High Very High
Dorsal horn 192 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 742 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 388 100.00 Very High Very High Very High
Nociception 384 100.00 Very High Very High Very High
Ganglion Cysts 364 100.00 Very High Very High Very High
Hot Flashes 78 100.00 Very High Very High Very High
Hypertension 73 100.00 Very High Very High Very High
Osteoporosis 72 100.00 Very High Very High Very High
Hypoxia 63 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 62 100.00 Very High Very High Very High
Heart Rate Under Development 29 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since earlier studies have shown that electrical stimulation of the Gasserian ganglion induces first accumulation then depletion of CGRP from perivascular sensory terminals in the dura mater, the present experiments suggest that CGRP is depleted also from central terminals of primary sensory trigeminal neurons, which might be of importance in the pathogenesis of migraine headache.
Negative_regulation (depletion) of CGRP in Gasserian ganglion associated with ganglion cysts, migraine, headache and calcitonin gene-related peptide
1) Confidence 0.59 Published 1998 Journal Exp Brain Res Section Abstract Doc Link 9547068 Disease Relevance 0.43 Pain Relevance 0.49
Depletion of calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat after electrical stimulation of the Gasserian ganglion.
Negative_regulation (Depletion) of calcitonin gene-related peptide in nucleus associated with ganglion cysts and calcitonin gene-related peptide
2) Confidence 0.59 Published 1998 Journal Exp Brain Res Section Title Doc Link 9547068 Disease Relevance 0.35 Pain Relevance 0.42
However, the decreased level of CGRP was only observed in the rats treated with a second capsaicin.
Negative_regulation (decreased) of CGRP associated with qutenza and calcitonin gene-related peptide
3) Confidence 0.59 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12832107 Disease Relevance 0.23 Pain Relevance 0.88
Electrical stimulation of the Gasserian ganglion resulted in partial depletion of calcitonin gene-related peptide (CGRP) from ipsilateral central terminals of pseudounipolar primary sensory ganglion cells.
Spec (partial) Negative_regulation (depletion) of calcitonin gene-related peptide in sensory ganglion associated with ganglion cysts and calcitonin gene-related peptide
4) Confidence 0.59 Published 1998 Journal Exp Brain Res Section Abstract Doc Link 9547068 Disease Relevance 0.34 Pain Relevance 0.28
Electrical stimulation of the Gasserian ganglion resulted in partial depletion of calcitonin gene-related peptide (CGRP) from ipsilateral central terminals of pseudounipolar primary sensory ganglion cells.
Spec (partial) Negative_regulation (depletion) of CGRP in sensory ganglion associated with ganglion cysts and calcitonin gene-related peptide
5) Confidence 0.59 Published 1998 Journal Exp Brain Res Section Abstract Doc Link 9547068 Disease Relevance 0.34 Pain Relevance 0.28
Numerous perikarya containing CGRP are present in the trigeminal ganglia, and surgical lesions of the trigeminal ganglia significantly reduce the levels of CGRP in the cerebral vasculature, suggesting that this cranial nerve is the principal origin of these cerebrovascular nerve fibers.
Negative_regulation (reduce) of CGRP in cranial nerve associated with calcitonin gene-related peptide
6) Confidence 0.59 Published 1985 Journal Neurosci. Lett. Section Abstract Doc Link 2415882 Disease Relevance 0.08 Pain Relevance 0.57
The loss of CGRP nerves demonstrated by immunocytochemistry was accompanied by a parallel reduction in the tissue content of CGRP, as measured by radioimmunoassay (1.5 +/- 0.5 pmol/g in capsaicin-treated animals compared with 9.4 +/- 1.9 pmol/g in vehicle-treated controls; p less than 0.0025).
Negative_regulation (reduction) of CGRP in nerves associated with qutenza and calcitonin gene-related peptide
7) Confidence 0.59 Published 1985 Journal Gastroenterology Section Abstract Doc Link 3871192 Disease Relevance 0.15 Pain Relevance 0.63
Down-regulation of CGRP receptors or altered post-receptor signalling may be involved in the reduced responsiveness to CGRP.
Negative_regulation (Down-regulation) of CGRP associated with calcitonin gene-related peptide
8) Confidence 0.59 Published 1997 Journal J Auton Pharmacol Section Abstract Doc Link 9234082 Disease Relevance 0 Pain Relevance 0.83
CGRP-IR and SP-IR fibres were significantly reduced in numbers by the capsaicin treatment (by 58 and 49%, respectively), confirming the success of sensory denervation.
Negative_regulation (reduced) of CGRP-IR associated with qutenza, substance p and calcitonin gene-related peptide
9) Confidence 0.59 Published 2000 Journal Exp. Physiol. Section Abstract Doc Link 10662894 Disease Relevance 0.15 Pain Relevance 0.69
Acute administration of morphine decreases levels of CGRP in rat corpus striatum.
Negative_regulation (decreases) of CGRP in corpus striatum associated with calcitonin gene-related peptide and morphine
10) Confidence 0.59 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1335576 Disease Relevance 0 Pain Relevance 1.25
After intraperitoneal instillation of acid there was an increase in the plasma levels of somatostatin and a decrease of calcitonin gene-related peptide, but there was no change of neuropeptide Y, vasoactive intestinal peptide, substance P, neurokinin A, or neurotensin.
Negative_regulation (decrease) of calcitonin in plasma associated with neuropeptide, somatostatin, substance p and calcitonin gene-related peptide
11) Confidence 0.59 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9530148 Disease Relevance 0.07 Pain Relevance 0.23
The neurokinin A and calcitonin gene-related peptide content in lymph nodes, spleen and lung, but not the content of neuropeptide Y, was markedly decreased by capsaicin treatment, suggesting a sensory origin for the two former peptides.
Negative_regulation (decreased) of calcitonin in lymph nodes associated with qutenza, neuropeptide and calcitonin gene-related peptide
12) Confidence 0.59 Published 1990 Journal Cell Tissue Res. Section Abstract Doc Link 2175253 Disease Relevance 0.23 Pain Relevance 0.60
Pretreatment with dihydroergotamine (DHE) (50 micrograms/kg i.v.) did not change the baseline levels but decreased levels of CGRP during stimulation (0.3 mA), by 55% at 1 min and 50% at 3 min.
Neg (not) Negative_regulation (decreased) of CGRP associated with calcitonin gene-related peptide
13) Confidence 0.59 Published 1991 Journal Neuropharmacology Section Abstract Doc Link 1663596 Disease Relevance 0.28 Pain Relevance 0.63
The results of cystometry with capsaicin in liposomes and capsaicin in 30% ethanol correlated with a significant decrease in calcitonin gene-related peptide staining of afferent nerves in the bladder wall.
Negative_regulation (decrease) of calcitonin in nerves
14) Confidence 0.59 Published 2004 Journal J. Urol. Section Body Doc Link 14665960 Disease Relevance 0 Pain Relevance 0
Also in dorsal root ganglia of non-arthritic rats, budesonide had an effect, with reduced calcitonin gene-related peptide messenger RNA levels below constitutive concentrations.
Negative_regulation (reduced) of calcitonin in dorsal root ganglia associated with arthritis and calcitonin gene-related peptide
15) Confidence 0.59 Published 1999 Journal Neuroscience Section Abstract Doc Link 10465459 Disease Relevance 1.01 Pain Relevance 0.77
In spinal motoneurons of arthritic rats, marked decreases in calcitonin gene-related peptide messenger RNA and protein levels were measured.
Negative_regulation (decreases) of calcitonin in motoneurons associated with arthritis and calcitonin gene-related peptide
16) Confidence 0.59 Published 1999 Journal Neuroscience Section Abstract Doc Link 10465459 Disease Relevance 0.89 Pain Relevance 0.74
Age-related decrease of calcitonin gene-related peptide-containing vasodilator innervation in the mesenteric resistance vessel of the spontaneously hypertensive rat.
Negative_regulation (decrease) of calcitonin associated with hypertension and calcitonin gene-related peptide
17) Confidence 0.59 Published 1990 Journal Circ. Res. Section Title Doc Link 2397578 Disease Relevance 0.44 Pain Relevance 0.37
Capsaicin induces a depletion of calcitonin gene-related peptide (CGRP)-immunoreactive nerves in the cardiovascular system of the guinea pig and rat.
Negative_regulation (depletion) of CGRP in cardiovascular system associated with qutenza and calcitonin gene-related peptide
18) Confidence 0.59 Published 1986 Journal J. Auton. Nerv. Syst. Section Title Doc Link 2427561 Disease Relevance 0 Pain Relevance 0.80
Capsaicin induces a depletion of calcitonin gene-related peptide (CGRP)-immunoreactive nerves in the cardiovascular system of the guinea pig and rat.
Negative_regulation (depletion) of calcitonin gene-related peptide in cardiovascular system associated with qutenza and calcitonin gene-related peptide
19) Confidence 0.59 Published 1986 Journal J. Auton. Nerv. Syst. Section Title Doc Link 2427561 Disease Relevance 0 Pain Relevance 0.80
Simultaneous depletion of neurokinin A, substance P and calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat during electrical stimulation of the trigeminal ganglion.
Negative_regulation (depletion) of calcitonin gene-related peptide in nucleus associated with ganglion cysts, trigeminal ganglion, calcitonin gene-related peptide and substance p
20) Confidence 0.59 Published 2000 Journal Pain Section Title Doc Link 10666545 Disease Relevance 0.67 Pain Relevance 0.93

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