INT254001

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.52
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 27
Disease Relevance 14.17
Pain Relevance 7.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) endosome (Cxcr4) aging (Mif)
cytoplasm (Mif) signal transducer activity (Cxcr4) cell proliferation (Mif)
Anatomy Link Frequency
bladder 22
urothelial cells 1
T cells 1
Cxcr4 (Rattus norvegicus)
Mif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 891 100.00 Very High Very High Very High
chemokine 513 100.00 Very High Very High Very High
cytokine 162 95.90 Very High Very High Very High
Stimulus evoked pain 54 91.84 High High
dorsal root ganglion 108 81.68 Quite High
anesthesia 27 78.72 Quite High
substance P 27 69.44 Quite High
Inflammatory stimuli 27 63.56 Quite High
Lasting pain 27 58.04 Quite High
Crohn's disease 27 56.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 918 100.00 Very High Very High Very High
Cystitis 459 100.00 Very High Very High Very High
Bladder Cancer 81 98.20 Very High Very High Very High
Injury 162 97.72 Very High Very High Very High
Colon Cancer 27 97.68 Very High Very High Very High
Inflammatory Bowel Disease 27 96.40 Very High Very High Very High
Pain 81 91.84 High High
Hypersensitivity 54 91.44 High High
Body Weight 135 81.84 Quite High
Ganglion Cysts 108 80.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclophosphamide upregulated bladder CXCR4 expression: MIF-CXCR4 associations in the bladder
CXCR4 Binding (associations) of MIF in bladder
1) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
MIF, however, competed with the recognized ligand for CXCR4 (SDF-1/CXCL12) for binding to CXCR4 [18].
CXCR4 Binding (ligand) of MIF
2) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.50 Pain Relevance 0.28
Note that most of the bladder MIF did not stick to the CXCR4 antibody column (“Flow-through”) and is not associated with CXCR4.
CXCR4 Binding (associated) of MIF in bladder
3) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.11 Pain Relevance 0.06
Therefore, although, not directly tested in this study, our results suggest that MIF in the bladder may participate in bladder inflammation either through binding to CXCR4 in the urothelium (formerly thought to only bind SDF-1 but recently shown to also bind MIF [18]) or to CD74 (recognized binding protein for MIF which is upregulated in bladder inflammation [6]) to activate signal transduction pathways that result in the production of other inflammatory cytokines.
CXCR4 Binding (binding) of MIF in bladder associated with inflammation and cytokine
4) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.50 Pain Relevance 0.40
However, recent in vitro evidence showed that CXCR4 is also capable of binding MIF [18].
CXCR4 Binding (binding) of MIF
5) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.33 Pain Relevance 0.29
The results from the present study indicate that MIF, by associating with CXCR4 receptors in the bladder (presumably urothelial in origin), may be competing with SDF-1 at CXCR4 receptors to participate in epithelial repair following injury.
CXCR4 Binding (competing) of MIF in bladder associated with injury
6) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.26 Pain Relevance 0.66
We studied whether CXCR4-MIF associations occur in rat bladder and the effect of experimental cystitis.


CXCR4 Binding (associations) of MIF in bladder associated with cystitis
7) Confidence 0.38 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2588654 Disease Relevance 0.45 Pain Relevance 0.22
These data demonstrate CXCR4-MIF associations occur in vivo in rat bladder and increase in experimental cystitis.
CXCR4 Binding (associations) of MIF in bladder associated with cystitis
8) Confidence 0.38 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2588654 Disease Relevance 0.40 Pain Relevance 0.15
Immunoprecipitation demonstrated an association between CXCR4 and MIF in the bladder.
CXCR4 Binding (association) of MIF in bladder
9) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.56 Pain Relevance 0.46
We studied whether CXCR4-MIF associations occur in rat bladder and the effect of experimental cystitis.


CXCR4 Binding (associations) of MIF in bladder associated with cystitis
10) Confidence 0.38 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2588654 Disease Relevance 0.45 Pain Relevance 0.22
Therefore, we hypothesized that CXCR4-MIF complex formation may also occur in the bladder (as described occurring in vitro [18]).
CXCR4 Binding (formation) of MIF in bladder
11) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.54 Pain Relevance 0.29
The exact role of CXCR4 and MIF-CXCR4 associations in the bladder was not addressed in the present study and remains to be investigated.
CXCR4 Binding (associations) of MIF in bladder
12) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.56 Pain Relevance 0.27
Cyclophosphamide upregulated bladder CXCR4 expression: MIF-CXCR4 associations in the bladder
CXCR4 Binding (associations) of MIF in bladder
13) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
Therefore, we hypothesized that CXCR4-MIF complex formation may also occur in the bladder (as described occurring in vitro [18]).
CXCR4 Binding (formation) of MIF in bladder
14) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.54 Pain Relevance 0.29
In this study we confirm these in vitro finding since we demonstrate 1) co-localization of CXCR4 and MIF in the urothelium, both in saline treated rats and after CYP treatment; 2) CXCR4-MIF associations are present in saline-treated bladder and increase after CYP treatment.
CXCR4 Binding (associations) of MIF in bladder
15) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.44 Pain Relevance 0.37
Therefore, we examined: 1) location of cytokine receptor CXCR4 in the rat bladder; 2) baseline bladder levels of SDF-1 (cognate ligand for CXCR4) and changes in response to a chemically-induced (cyclophosphamide; CYP) model of bladder inflammation; 3) CXCR4 expression changes after CYP-induced cystitis and 4) association between CXCR4 and MIF in the bladder before and after CYP-induced cystitis.
CXCR4 Binding (association) of MIF in bladder associated with inflammation, cystitis and cytokine
16) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.81 Pain Relevance 0.21
The results from the present study indicate that MIF, by associating with CXCR4 receptors in the bladder (presumably urothelial in origin), may be competing with SDF-1 at CXCR4 receptors to participate in epithelial repair following injury.
CXCR4 Binding (associating) of MIF in bladder associated with injury
17) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.15 Pain Relevance 0.62
These data demonstrate CXCR4-MIF associations occur in vivo in rat bladder and increase in experimental cystitis.
CXCR4 Binding (associations) of MIF in bladder associated with cystitis
18) Confidence 0.38 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2588654 Disease Relevance 0.40 Pain Relevance 0.15
Recently, however, a novel functional association between MIF and chemokine receptors CXCR2 and CXCR4 was described in T cells in vitro [18].
CXCR4 Binding (association) of MIF in T cells associated with chemokine
19) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.81 Pain Relevance 0.44
Therefore, we examined: 1) location of cytokine receptor CXCR4 in the rat bladder; 2) baseline bladder levels of SDF-1 (cognate ligand for CXCR4) and changes in response to a chemically-induced (cyclophosphamide; CYP) model of bladder inflammation; 3) CXCR4 expression changes after CYP-induced cystitis and 4) association between CXCR4 and MIF in the bladder before and after CYP-induced cystitis.
CXCR4 Binding (association) of MIF in bladder associated with inflammation, cystitis and cytokine
20) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.82 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox