INT254045

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 3.04
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (TRIP10) cytoplasm (TRIP10) cytosol (TRIP10)
lipid binding (TRIP10) signal transduction (TRIP10) cytoskeleton (TRIP10)
Anatomy Link Frequency
neurons 1
ACC neurons 1
TRIP10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 324 100.00 Very High Very High Very High
Pain 94 98.16 Very High Very High Very High
carbamazepine 14 94.24 High High
central sensitization 28 91.68 High High
anticonvulsant 12 90.16 High High
nMDA receptor 46 87.32 High High
GABA receptor 4 86.48 High High
Sciatic nerve 8 86.32 High High
fibrosis 1 83.80 Quite High
Lasting pain 80 83.52 Quite High
Disease Link Frequency Relevance Heat
Nociception 240 99.76 Very High Very High Very High
Syndrome 292 99.16 Very High Very High Very High
Pain 178 98.16 Very High Very High Very High
Myoclonic Epilepsies 6 97.32 Very High Very High Very High
Epilepsy 194 97.28 Very High Very High Very High
Influenza Virus Infection 22 93.72 High High
Convulsion 250 91.56 High High
Infection 7 88.80 High High
Cystic Fibrosis 1 83.80 Quite High
Pseudomonas Infection 1 79.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicated that the presynaptic calcium influx is an important mechanism that regulates the expression of the STP in the layer II/III ACC neurons.
Gene_expression (expression) of STP in ACC neurons associated with anterior cingulate cortex
1) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2745374 Disease Relevance 0.30 Pain Relevance 0.34
Unique Features of MITN/ACC STP
Gene_expression (/) of STP associated with anterior cingulate cortex
2) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2745374 Disease Relevance 0.10 Pain Relevance 0.27
Thus, layer II/III neurons express an STP that is calcium dependent and involves glutamatergic transmission.
Gene_expression (express) of STP in neurons
3) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2745374 Disease Relevance 0 Pain Relevance 0.18
The hypothesis guiding our studies of the thalamocingulate circuit is that the nociceptive MITN input generates STP in ACC and may be a precursor to longer term pain processing events.


Gene_expression (generates) of STP associated with nociception, pain and anterior cingulate cortex
4) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2745374 Disease Relevance 0.46 Pain Relevance 0.39
This demonstration of the importance of bacterial neuraminidases in biofilm formation indicates the possible vulnerability of STP biofilms to OC exposure during a pandemic.
Gene_expression (exposure) of STP
5) Confidence 0.11 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592279 Disease Relevance 0.50 Pain Relevance 0.04
STP was first identified in 1978 with clinical trials starting in the 1980s in all forms of epileptic syndromes, including LGS in which it was used in combination with CBZ (Tran et al 1996).
Gene_expression (identified) of STP associated with epilepsy, syndrome and carbamazepine
6) Confidence 0.05 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 0.92 Pain Relevance 0.20
At the present time, STP is mainly used in Dravet and related syndromes added to CLB and VPA.
Gene_expression (used) of STP associated with syndrome
7) Confidence 0.05 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 0.76 Pain Relevance 0.25

General Comments

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