INT254053

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CDH6) nucleolus (CDH6) plasma membrane (CDH6)
nucleus (CDH6) cytoplasm (CDH6)
CDH6 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 102 98.28 Very High Very High Very High
Ovarian Cancer 183 95.00 High High
Disease 72 94.64 High High
Carcinoma 78 86.08 High High
Endometroid Carcinoma 6 71.20 Quite High
Residual Neoplasm 3 55.12 Quite High
Abdominal Pain 3 25.00 Low Low
Death 15 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 3 5.00 Very Low Very Low Very Low
Breast Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many of the markers expressed in other subtypes were either infrequently (<10%) expressed (p53, ER, PAX8, SLPI, K-Cadherin, and CA125), or completely absent (CRABP2, WT-1, and Mesothelin).
Neg (absent) Gene_expression (expressed) of K-Cadherin
1) Confidence 0.02 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2592352 Disease Relevance 0.29 Pain Relevance 0
In this retrospective study we assessed the protein expression of 21 candidate tissue-based biomarkers (CA125, CRABP-II, EpCam, ER, F-Spondin, HE4, IGF2, K-Cadherin, Ki-67, KISS1, Matriptase, Mesothelin, MIF, MMP7, p21, p53, PAX8, PR, SLPI, TROP2, WT1) in a population-based cohort of 500 ovarian carcinomas that was collected over the period from 1984 to 2000.
Gene_expression (expression) of K-Cadherin associated with ovarian cancer
2) Confidence 0.02 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2592352 Disease Relevance 0.54 Pain Relevance 0
Comparing biomarker expression in the entire cohort for tumors diagnosed at different stages revealed that ten biomarkers (CRABP-II, ER, F-Spondin, K-Cadherin, Ki-67, Matriptase, Mesothelin, p21, p53, and WT1) had significantly different expression levels between stages, suggesting differences between “early” and “late” stage disease (Figure 2, Table S2).
Gene_expression (p21) of K-Cadherin associated with cancer and disease
3) Confidence 0.01 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2592352 Disease Relevance 0.65 Pain Relevance 0

General Comments

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