INT254072

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 8.29
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (SEPT5) plasma membrane (SEPT5) cytoskeleton (SEPT5)
cell cycle (SEPT5) GTPase activity (SEPT5) cytoplasm (SEPT5)
Anatomy Link Frequency
colon 5
small intestine 5
nasal 2
cardiac myocytes 1
cleavage 1
SEPT5 (Homo sapiens)
Pain Link Frequency Relevance Heat
spastic colon 132 91.80 High High
agonist 407 90.48 High High
depression 22 85.52 High High
Migraine 77 79.36 Quite High
Potency 37 77.60 Quite High
cytokine 80 66.44 Quite High
antidepressant 33 56.80 Quite High
Piles 3 54.96 Quite High
Endep 11 54.80 Quite High
antagonist 169 47.28 Quite Low
Disease Link Frequency Relevance Heat
Infection 263 99.28 Very High Very High Very High
Immunization 221 98.68 Very High Very High Very High
Hypersensitivity 78 98.36 Very High Very High Very High
Influenza Virus Infection 373 97.04 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

99 91.80 High High
Sprains And Strains 260 90.04 High High
Death 12 86.80 High High
Disease 54 86.52 High High
Depression 22 85.52 High High
Anxiety Disorder 33 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The current state of knowledge shows the human small intestine and colon also express h5–HT4(d) and that this is not found in other tissues [13,15,56].
Gene_expression (express) of h5 in small intestine
1) Confidence 0.16 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.06 Pain Relevance 0
More recent experiments using adenoviral expression of h5–HT4(b) and 5–HT4(d) splice variants in rodent cardiac myocytes that do not naturally express 5–HT4 receptors demonstrated that the 5–HT4(d) receptor was more efficiently coupled to adenylyl cyclase [23].
Gene_expression (expression) of h5 in cardiac myocytes
2) Confidence 0.16 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.08 Pain Relevance 0.09
However, h5–HT7(d) was reported later to be predominantly expressed in the human small intestine and colon together with a certain amount of the h5–HT7(d+5) fragment [43].
Gene_expression (expressed) of h5 in small intestine
3) Confidence 0.16 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.07 Pain Relevance 0.05
However, h5–HT7(d) was reported later to be predominantly expressed in the human small intestine and colon together with a certain amount of the h5–HT7(d+5) fragment [43].
Gene_expression (expressed) of h5 in small intestine
4) Confidence 0.14 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.07 Pain Relevance 0.06
All 5–HT7 receptor splice variants are expressed in the human small intestine and colon including a certain amount of the h5–HT7(d+5) fragment [43].
Gene_expression (expressed) of h5 in small intestine
5) Confidence 0.14 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.33 Pain Relevance 0.32
The human small intestine and colon express various h5–HT4 splice variants (see Table 1, [13,15,56]).
Gene_expression (express) of h5 in small intestine
6) Confidence 0.13 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0 Pain Relevance 0.15
The current state of knowledge shows the human small intestine and colon also express h5–HT4(d) and that this is not found in other tissues [13,15,56].
Gene_expression (express) of h5 in colon
7) Confidence 0.06 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.06 Pain Relevance 0
However, h5–HT7(d) was reported later to be predominantly expressed in the human small intestine and colon together with a certain amount of the h5–HT7(d+5) fragment [43].
Gene_expression (expressed) of h5 in colon
8) Confidence 0.06 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.07 Pain Relevance 0.05
Briefly, whole N. benthamiana plants (41–44 days old) were vacuum infiltrated in batches with an Agrobacterium inoculum containing the H5 expression cassette.
Gene_expression (expression) of H5
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008737 Disease Relevance 0.12 Pain Relevance 0
All 5–HT7 receptor splice variants are expressed in the human small intestine and colon including a certain amount of the h5–HT7(d+5) fragment [43].
Gene_expression (expressed) of h5 in colon
10) Confidence 0.05 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.33 Pain Relevance 0.32
However, h5–HT7(d) was reported later to be predominantly expressed in the human small intestine and colon together with a certain amount of the h5–HT7(d+5) fragment [43].
Gene_expression (expressed) of h5 in colon
11) Confidence 0.05 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0.07 Pain Relevance 0.06
The lack of both allergic reactions and increases in IgE following vaccination may be explained by the fact that the H5 glycans present in this VLP vaccine bear terminal N-acetylglucosamine (GlcNAc). which could conceivably have shielded the more proximal ?
Gene_expression (present) of H5 in proximal associated with hypersensitivity
12) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008737 Disease Relevance 0.45 Pain Relevance 0
The human small intestine and colon express various h5–HT4 splice variants (see Table 1, [13,15,56]).
Gene_expression (express) of h5 in colon
13) Confidence 0.04 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0 Pain Relevance 0.15
13) were further tested for the presence of H5 or H7-specific viral RNA.
Gene_expression (presence) of H5
14) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812492 Disease Relevance 0.20 Pain Relevance 0
Starting at the lowest dose of H5 vaccine (5 µg/dose), groups of 16 subjects were randomized using block permutation to receive either active vaccine (n?
Gene_expression (vaccine) of H5
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008737 Disease Relevance 0.59 Pain Relevance 0
As shown in Fig. 6, H5 specific IgA antibodies in the nasal washes were detected in two of the seven animals after a single immunization, although all of the vaccinated animals responded after the second dose of the vaccine.


Gene_expression (antibodies) of H5 in nasal associated with immunization
16) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694350 Disease Relevance 0.64 Pain Relevance 0
Active H5 infection was confirmed only in one duck, by expression of H5-specific antibodies and detection of viral RNA in the various sample types (feces, water, oral and cloacal swabs) with a pattern similar to the H5-inoculated control bird.
Gene_expression (expression) of H5 in feces associated with infection
17) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812492 Disease Relevance 0.56 Pain Relevance 0
Besides for systemic cross-neutralizing antibodies, the induction of H5 specific mucosal IgA that was detected in some ferrets after the first immunization as well as the T-cell response may contribute to the protection of ferrets against a heterologous virus.
Gene_expression (detected) of H5 in T-cell associated with immunization
18) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694350 Disease Relevance 0.65 Pain Relevance 0.04
The final normalized results were expressed in H5-specific AU/100 AU of the total IgA for each individual nasal wash sample.


Gene_expression (expressed) of H5 in nasal
19) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694350 Disease Relevance 0.15 Pain Relevance 0
The polybasic cleavage site of HA was replaced by the sequence TETR/GLF, which was found to be genetically more stable in birds than the sequence (RETR/GLF) that is typical for avirulent H5 viruses and that is widely used for H5N1 vaccine development [47].
Gene_expression (viruses) of H5 in cleavage
20) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694350 Disease Relevance 0.22 Pain Relevance 0.10

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