INT254090

Context Info Confidence 0.10 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.63 Pain Relevance 0

mitochondrion (Bax) aging (EPO) endoplasmic reticulum (Bax) intracellular (Bax) cytoplasm (Bax) lipid binding (Bax)

EPO (Homo sapiens) Bax (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 7 5.00 anesthesia 3 5.00 isoflurane 2 5.00 ischemia 1 5.00 Immobilon 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 30 100.00 Acute Renal Failure 1 99.98 Death 6 89.08 Stroke 2 29.76 Anaemia 1 18.36 Injury 3 5.00 Cirrhosis 2 5.00 Hematological Disease 2 5.00 Body Weight 2 5.00 Cancer 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Johnson et al. reported that in acute renal failure EPO decreased the expression of pro-apoptotic Bax and did not affect the expression of anti-apoptotic molecules Bcl-2 and Bcl-xL [15].

EPO Negative_regulation (decreased) of Gene_expression (expression) of Bax associated with acute renal failure and apoptosis

1) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2592699 Disease Relevance 0.63 Pain Relevance 0

General Comments

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