INT2541

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Context Info
Confidence 0.48
First Reported 1979
Last Reported 2010
Negated 9
Speculated 7
Reported most in Abstract
Documents 200
Total Number 207
Disease Relevance 67.14
Pain Relevance 134.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
nerve 12
spinal cord 11
neurons 8
IB4 7
dorsal horn 6
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 1581 100.00 Very High Very High Very High
substance P 450 100.00 Very High Very High Very High
qutenza 445 100.00 Very High Very High Very High
Inflammation 315 100.00 Very High Very High Very High
Pain 283 100.00 Very High Very High Very High
antagonist 255 100.00 Very High Very High Very High
headache 253 100.00 Very High Very High Very High
dorsal root ganglion 179 100.00 Very High Very High Very High
Neuropeptide 178 100.00 Very High Very High Very High
Spinal cord 177 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 357 100.00 Very High Very High Very High
INFLAMMATION 280 100.00 Very High Very High Very High
Pain 250 100.00 Very High Very High Very High
Hypoxia 41 100.00 Very High Very High Very High
Hypertension 17 100.00 Very High Very High Very High
Neuroma 12 100.00 Very High Very High Very High
Hypercalcemia 12 100.00 Very High Very High Very High
Hip Fractures 8 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 119 99.98 Very High Very High Very High
Pheochromocytoma 29 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative receptor autoradiography was used to evaluate potential alterations in substance P (SP) and calcitonin gene-related peptide (CGRP) binding in the L4 spinal segment of rats following unilateral poisoning of the sciatic nerve with pronase.
calcitonin gene-related peptide Binding (binding) of in sciatic nerve associated with sciatic nerve, poisoning, calcitonin gene-related peptide and substance p
1) Confidence 0.48 Published 1999 Journal Somatosens Mot Res Section Abstract Doc Link 10355881 Disease Relevance 0.10 Pain Relevance 0.67
Quantitative receptor autoradiography was used to evaluate potential alterations in substance P (SP) and calcitonin gene-related peptide (CGRP) binding in the L4 spinal segment of rats following unilateral poisoning of the sciatic nerve with pronase.
CGRP Binding (binding) of in sciatic nerve associated with sciatic nerve, poisoning, calcitonin gene-related peptide and substance p
2) Confidence 0.48 Published 1999 Journal Somatosens Mot Res Section Abstract Doc Link 10355881 Disease Relevance 0.10 Pain Relevance 0.67
Densitometric measurements revealed a 50% return towards normal values for SP binding by 90 days postpronase injection in all laminae examined, while the density of CGRP binding showed a partial return towards normal values for laminae III-IV only.
CGRP Spec (examined) Binding (binding) of associated with calcitonin gene-related peptide and substance p
3) Confidence 0.48 Published 1999 Journal Somatosens Mot Res Section Abstract Doc Link 10355881 Disease Relevance 0.08 Pain Relevance 0.71
Changes in substance P and calcitonin gene-related peptide binding in the dorsal horn of rat spinal cord following pronase-induced deafferentation.
calcitonin gene-related peptide Binding (binding) of in dorsal horn associated with neuralgia, dorsal horn, deafferentation, spinal cord, calcitonin gene-related peptide and substance p
4) Confidence 0.48 Published 1999 Journal Somatosens Mot Res Section Title Doc Link 10355881 Disease Relevance 0.09 Pain Relevance 0.85
The data suggest that pain perception is linked to complex interactions between CGRP, substance P, and enkephalin in sensory pathways and an intact peripheral input.
CGRP Binding (interactions) of associated with pain, enkephalin, substance p and calcitonin gene-related peptide
5) Confidence 0.48 Published 1991 Journal J. Mol. Neurosci. Section Abstract Doc Link 1715733 Disease Relevance 0.44 Pain Relevance 1.40
Measurements of the binding of 125I-labelled CGRP in the dorsal spinal cord indicate that high affinity binding sites for CGRP are downregulated at 4 days after injection of CFA.
CGRP Binding (binding) of in spinal cord associated with calcitonin gene related peptide and spinal cord
6) Confidence 0.48 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8846392 Disease Relevance 0.49 Pain Relevance 1.32
We conclude that CGRP immunoreactivity is localized in both nerve fibres and endocrine cells and is associated principally with the afferent (sensory) innervation of the respiratory tract.
CGRP Binding (associated) of in respiratory tract associated with calcitonin gene-related peptide
7) Confidence 0.48 Published 1986 Journal Neuroscience Section Abstract Doc Link 3490633 Disease Relevance 0.08 Pain Relevance 0.48
The pattern of binding of [125I]calcitonin gene-related peptide was not or only minimally changed by innocuous mechanical stimuli (flexion of and innocuous pressure to the knee in the cat and innocuous pressure to the knee of the rat) but was significantly altered by electrical stimulation of the tibial nerve in the cat (sufficient to excite unmyelinated afferent fibres), indicating release of the peptide by the latter stimulus.
calcitonin Binding (binding) of in knee associated with unmyelinated and calcitonin gene-related peptide
8) Confidence 0.48 Published 1994 Journal Neuroscience Section Abstract Doc Link 7845599 Disease Relevance 0.31 Pain Relevance 0.62
During the first hours of the development of an experimental inflammation in the knee joint induced by intra-articular injections of kaolin and carrageenan, the pattern of binding of [125I]calcitonin gene-related peptide changed.
calcitonin Binding (binding) of in articular associated with inflammation and calcitonin gene-related peptide
9) Confidence 0.48 Published 1994 Journal Neuroscience Section Abstract Doc Link 7845599 Disease Relevance 0.36 Pain Relevance 0.67
These results demonstrate the existence of specific interaction between CGRP and the development of tolerance to the spinal antinociceptive effects of morphine.
CGRP Binding (interaction) of in spinal associated with tolerance, antinociceptive, morphine and calcitonin gene-related peptide
10) Confidence 0.48 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8601814 Disease Relevance 0 Pain Relevance 2.03
Calcitonin gene-related peptide does not interact with sympathetic activity in myocardial ischemia.
Calcitonin gene-related peptide Neg (not) Binding (interact) of in sympathetic associated with coronary artery disease, ischemia and calcitonin gene-related peptide
11) Confidence 0.48 Published 2005 Journal Regul. Pept. Section Title Doc Link 15582720 Disease Relevance 0.27 Pain Relevance 0.66
The dorsal horn of the spinal cord, which forms the locus of first synapses in pain pathways, is an important site of interaction between calcitonin gene-related peptide (CGRP), substance P and enkephalin--the neuropeptides considered to be especially involved in the regulation of pain perception.
CGRP Binding (interaction) of in spinal cord associated with pain, neuropeptide, dorsal horn, enkephalin, substance p, calcitonin gene-related peptide and spinal cord
12) Confidence 0.48 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7517279 Disease Relevance 0.51 Pain Relevance 1.24
The dorsal horn of the spinal cord, which forms the locus of first synapses in pain pathways, is an important site of interaction between calcitonin gene-related peptide (CGRP), substance P and enkephalin--the neuropeptides considered to be especially involved in the regulation of pain perception.
calcitonin gene-related peptide Binding (interaction) of in spinal cord associated with pain, neuropeptide, dorsal horn, enkephalin, substance p, calcitonin gene-related peptide and spinal cord
13) Confidence 0.48 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7517279 Disease Relevance 0.50 Pain Relevance 1.24
After intense electrical stimulation or K(+)-induced depolarization, CGRP can be released from nerve terminals and bound to receptors on sarcolemma.
CGRP Binding (bound) of in nerve associated with calcitonin gene-related peptide
14) Confidence 0.48 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8447372 Disease Relevance 0 Pain Relevance 0.32
Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord.
calcitonin Binding (Interactions) of in spinal cord associated with pain, spinal cord, excitatory amino acid, calcitonin gene-related peptide and substance p
15) Confidence 0.48 Published 1990 Journal Pain Section Title Doc Link 1700356 Disease Relevance 0 Pain Relevance 0.99
The underlying mechanism appears to be independent of the cGMP pathway and not to interact with CGRP in the trigeminal ganglion.
CGRP Neg (not) Binding (interact) of in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion and calcitonin gene-related peptide
16) Confidence 0.48 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19864020 Disease Relevance 0.31 Pain Relevance 0.70
Interaction of calcitonin gene-related peptide, nitric oxide and histamine release in neurogenic blood flow and afferent activation in the rat cranial dura mater.
calcitonin gene-related peptide Binding (Interaction) of in blood associated with headache and calcitonin gene-related peptide
17) Confidence 0.48 Published 2007 Journal Cephalalgia Section Title Doc Link 17441973 Disease Relevance 0.18 Pain Relevance 0.72
In animals with intact nerves, SP and CGRP had a strong synergistic effect, whereas VIP and CGRP had a weak facilitatory interaction.
CGRP Binding (interaction) of in nerves associated with calcitonin gene-related peptide and substance p
18) Confidence 0.48 Published 1989 Journal Brain Res. Section Abstract Doc Link 2472853 Disease Relevance 0.05 Pain Relevance 1.18
In animals with sectioned nerves, SP and CGRP did not interact, whereas VIP and CGRP had a stronger facilitatory interaction.
CGRP Binding (interaction) of in nerves associated with calcitonin gene-related peptide and substance p
19) Confidence 0.48 Published 1989 Journal Brain Res. Section Abstract Doc Link 2472853 Disease Relevance 0 Pain Relevance 1.09
CGRP binding was seen in the vascular endothelium and was significantly elevated after 5 days of hypoxia (mean +/- SEM: control 4.6 +/- 0.4 versus hypoxic 16.6 +/- 2.4 amol.mm-2).
CGRP Binding (binding) of in vascular endothelium associated with hypoxia and calcitonin gene-related peptide
20) Confidence 0.48 Published 1995 Journal Eur. Respir. J. Section Abstract Doc Link 8666097 Disease Relevance 0.82 Pain Relevance 0.71

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