INT25411

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Context Info
Confidence 0.48
First Reported 1989
Last Reported 2004
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.50
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) plasma membrane (Drd2) signal transducer activity (Drd2)
Anatomy Link Frequency
brain 2
striatum 2
Drd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 13 100.00 Very High Very High Very High
dopamine receptor 2 100.00 Very High Very High Very High
cocaine 11 99.80 Very High Very High Very High
Enkephalin 3 99.22 Very High Very High Very High
addiction 3 98.88 Very High Very High Very High
depression 2 95.12 Very High Very High Very High
antidepressant 3 94.56 High High
Buprenorphine 3 90.16 High High
tricyclic antidepressant 1 88.40 High High
agonist 4 86.28 High High
Disease Link Frequency Relevance Heat
Drug Dependence 3 98.88 Very High Very High Very High
Depressive Disorder 1 95.48 Very High Very High Very High
Disease 1 93.12 High High
Depression 1 82.48 Quite High
Aggression 1 55.44 Quite High
Attention Deficit Hyperactivity Disorder 1 48.80 Quite Low
Toxicity 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that several treatment regimens for cocaine addiction alter the cardiovascular responses to cocaine and that dopamine D2 receptor activation may be necessary for the decrease in cardiac output noted in vascular responders.
Spec (may) Positive_regulation (necessary) of Positive_regulation (activation) of dopamine D2 receptor associated with addiction, dopamine and cocaine
1) Confidence 0.48 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353374 Disease Relevance 0.17 Pain Relevance 0.68
Medial forebrain bundle stimulation or D-2 dopamine receptor activation increases preproenkephalin mRNA in rat striatum.
Positive_regulation (increases) of Positive_regulation (activation) of D-2 dopamine receptor in striatum associated with dopamine receptor and enkephalin
2) Confidence 0.47 Published 1989 Journal J. Neurochem. Section Title Doc Link 2521894 Disease Relevance 0 Pain Relevance 0.52
Regional analysis of labeling showed that the increased GAD67, preproenkephalin or dopamine D2 receptor mRNA levels occurred in all striatal sectors examined.
Positive_regulation (occurred) of Spec (examined) Positive_regulation (increased) of dopamine D2 receptor associated with dopamine
3) Confidence 0.42 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902185 Disease Relevance 0 Pain Relevance 0.45
Combined treatment with IMI and AMA also induces up-regulation of dopamine D2 and D3 receptors in the rat brain, and appears to be effective in the treatment of patients with drug-resistant unipolar depression.
Positive_regulation (induces) of Positive_regulation (up-regulation) of dopamine D2 in brain associated with dopamine, depression and depressive disorder
4) Confidence 0.15 Published 2004 Journal Behav Pharmacol Section Abstract Doc Link 15096916 Disease Relevance 0.33 Pain Relevance 0.33

General Comments

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