INT254115

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.91
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
nucleus 4
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 18 99.98 Very High Very High Very High
Inflammation 59 98.56 Very High Very High Very High
chemokine 13 69.92 Quite High
tolerance 18 67.64 Quite High
antagonist 17 65.12 Quite High
cytokine 26 54.16 Quite High
adenocard 73 50.00 Quite Low
Central nervous system 5 26.16 Quite Low
cva 1 19.08 Low Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 163 98.68 Very High Very High Very High
Pneumonia 20 98.56 Very High Very High Very High
Necrosis 1 98.44 Very High Very High Very High
Metastasis 92 94.80 High High
Skin Cancer 16 94.36 High High
INFLAMMATION 45 77.60 Quite High
Adult Respiratory Distress Syndrome 61 76.48 Quite High
Stress 10 75.68 Quite High
Disease 23 68.00 Quite High
Lewis Lung Carcinoma 2 66.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are consensually supported by the studies in which TLR4 activation inhibits phosphorylation and nucleus translocation of Stat3 [21] and activated Stat3 inhibits TLR4 signaling in return via inhibiting transcriptional or translational activity of NF-?
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of TLR4 in nucleus
1) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.28 Pain Relevance 0.12
These results are consensually supported by the studies in which TLR4 activation inhibits phosphorylation and nucleus translocation of Stat3 [21] and activated Stat3 inhibits TLR4 signaling in return via inhibiting transcriptional or translational activity of NF-?
Negative_regulation (supported) of Phosphorylation (phosphorylation) of TLR4 in nucleus
2) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.30 Pain Relevance 0.12
Kinase phosphorylation downstream of ceramide/TLR4
Negative_regulation (downstream) of Phosphorylation (phosphorylation) of TLR4
3) Confidence 0.26 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.13 Pain Relevance 0
As shown in Figure 2C, pretreatment with TLR4 antibody also inhibited LPS-stimulated phosphorylation of NF-?
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of LPS
4) Confidence 0.22 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.15 Pain Relevance 0.04
In addition, the same A2A agonist reduced LPS-induced microvascular permeability and secretion of interleukin-6, tumor necrosis factor-?
Negative_regulation (reduced) of Phosphorylation (permeability) of LPS associated with necrosis, cancer and agonist
5) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 1.04 Pain Relevance 0.44

General Comments

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