INT254118

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 2.54
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora2a) plasma membrane (Adora2a) enzyme binding (Adora2a)
signal transducer activity (Adora2a)
Anatomy Link Frequency
basophils 5
monocytes 1
lymphocytes 1
neutrophils 1
Adora2a (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 15 100.00 Very High Very High Very High
adenocard 110 99.70 Very High Very High Very High
Inflammation 38 99.04 Very High Very High Very High
Glutamate 8 91.52 High High
methotrexate 280 89.68 High High
addiction 28 78.60 Quite High
chemokine 2 70.40 Quite High
antagonist 25 65.60 Quite High
Arthritis 108 50.00 Quite Low
Eae 2 30.40 Quite Low
Disease Link Frequency Relevance Heat
Pneumonia 20 99.04 Very High Very High Very High
Cancer 9 97.12 Very High Very High Very High
Necrosis 1 96.88 Very High Very High Very High
INFLAMMATION 26 96.68 Very High Very High Very High
Psychosis 48 96.24 Very High Very High Very High
Drug Dependence 7 90.28 High High
Death 4 82.36 Quite High
Adult Respiratory Distress Syndrome 61 73.36 Quite High
Disease 52 64.88 Quite High
Hypersensitivity 1 60.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Defining variants of the ADORA2A gene
Negative_regulation (Defining) of Gene_expression (variants) of ADORA2A gene
1) Confidence 0.42 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2939586 Disease Relevance 0.47 Pain Relevance 0.07
Adenosine's effect is also mediated by adenosine A2 receptors (ADORA2), which are present on neutrophils, monocytes, lymphocytes and basophils, generally suppressing the immune function of these cells [32].
Negative_regulation (suppressing) of Gene_expression (present) of ADORA2 in basophils associated with adenocard
2) Confidence 0.35 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.26 Pain Relevance 0.48
Adenosine's effect is also mediated by adenosine A2 receptors (ADORA2), which are present on neutrophils, monocytes, lymphocytes and basophils, generally suppressing the immune function of these cells [32].
Negative_regulation (suppressing) of in monocytes Gene_expression (present) of ADORA2 in basophils associated with adenocard
3) Confidence 0.12 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.26 Pain Relevance 0.48
Adenosine's effect is also mediated by adenosine A2 receptors (ADORA2), which are present on neutrophils, monocytes, lymphocytes and basophils, generally suppressing the immune function of these cells [32].
Negative_regulation (suppressing) of in neutrophils Gene_expression (present) of ADORA2 in basophils associated with adenocard
4) Confidence 0.12 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.26 Pain Relevance 0.48
Adenosine's effect is also mediated by adenosine A2 receptors (ADORA2), which are present on neutrophils, monocytes, lymphocytes and basophils, generally suppressing the immune function of these cells [32].
Negative_regulation (suppressing) of in lymphocytes Gene_expression (present) of ADORA2 in basophils associated with adenocard
5) Confidence 0.12 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.26 Pain Relevance 0.48
In addition, the same A2A agonist reduced LPS-induced microvascular permeability and secretion of interleukin-6, tumor necrosis factor-?
Negative_regulation (reduced) of Gene_expression (agonist) of A2A associated with necrosis, cancer and agonist
6) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 1.03 Pain Relevance 0.44

General Comments

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