INT254143

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 13.81
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (CC2D1A) microtubule organizing center (CC2D1A) cytoplasm (CC2D1A)
signal transducer activity (CC2D1A) signal transduction (CC2D1A) nucleolus (CC2D1A)
Anatomy Link Frequency
lung 1
CC2D1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 55 99.34 Very High Very High Very High
agonist 15 98.98 Very High Very High Very High
dopamine receptor 5 96.92 Very High Very High Very High
Inflammation 15 95.76 Very High Very High Very High
aspirin 8 95.52 Very High Very High Very High
cINOD 34 94.48 High High
methotrexate 6 92.96 High High
adenocard 10 74.44 Quite High
ischemia 24 72.52 Quite High
vincristine 3 56.84 Quite High
Disease Link Frequency Relevance Heat
Injury 1777 100.00 Very High Very High Very High
Chronic Renal Failure 140 97.48 Very High Very High Very High
INFLAMMATION 89 95.76 Very High Very High Very High
Volume Depletion And Dehydration 16 92.64 High High
Renal Disease 315 90.96 High High
Cardiovascular Disease 6 90.24 High High
Hypoxia 151 89.72 High High
Uremia 17 89.52 High High
Hypertension 17 88.00 High High
Sepsis 61 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, on a global scale, the prevention of AKI is likely to have a larger impact on mortality rates than other measures.
Negative_regulation (prevention) of AKI associated with injury
1) Confidence 0.35 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.35 Pain Relevance 0.10
Endothelin receptor agonist for the A receptor have been shown to be shown to decrease AKI in animal models [42].
Negative_regulation (decrease) of AKI associated with injury and agonist
2) Confidence 0.25 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.31 Pain Relevance 0.05
Diuretics and ‘renal-dose’ dopamine are commonly used to prevent or limit AKI.
Negative_regulation (limit) of AKI associated with dopamine and injury
3) Confidence 0.25 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 0.89 Pain Relevance 0.30
the definition of AKI in children is well established: true or falsethe serum creatinine is a sensitive marker of AKI: true or falsein utero exposure to ACE inhibitors is associated with AKI in neonates: true or falseAKI in hospitalized children may be the result of multiple etiologies: true or falseurinary sodium concentration is a reliable indicator of pre-renal versus hypoxic/ischemic AKI in premature newborns: true or falseHypoxic/ischemic AKI
Negative_regulation (definition) of AKI associated with hypoxia and injury
4) Confidence 0.25 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.38 Pain Relevance 0.05
the definition of AKI in children is well established: true or falsethe serum creatinine is a sensitive marker of AKI: true or falsein utero exposure to ACE inhibitors is associated with AKI in neonates: true or falseAKI in hospitalized children may be the result of multiple etiologies: true or falseurinary sodium concentration is a reliable indicator of pre-renal versus hypoxic/ischemic AKI in premature newborns: true or falseHypoxic/ischemic AKI
Negative_regulation (marker) of AKI associated with hypoxia and injury
5) Confidence 0.25 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.36 Pain Relevance 0.05
We found that AKI was preceded by lung dysfunction in almost all of the cases, as has previously been claimed by Sheridan and colleagues [14].
Negative_regulation (preceded) of AKI in lung associated with injury
6) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2592761 Disease Relevance 1.45 Pain Relevance 0
The decreased activity of P-gp and OATs in AKI would contribute to decreased drug clearance and may potentially result in increased drug exposure.


Negative_regulation (decreased) of AKI associated with injury
7) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.84 Pain Relevance 0.28
From Table 2 it is apparent that, depending on the drug that is studied, AKI may increase, decrease, or have no effect on hepatic drug metabolism.
Negative_regulation (decrease) of AKI associated with injury
8) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.96 Pain Relevance 0
The number of studies addressing changes in hepatic metabolism in AKI is far more limited.
Negative_regulation (metabolism) of AKI associated with injury
9) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.94 Pain Relevance 0
Because of the high mortality rates, prevention of AKI in severe trauma patients admitted to the ICU remains crucial.
Negative_regulation (prevention) of AKI associated with injury
10) Confidence 0.04 Published 2010 Journal Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine Section Body Doc Link PMC3021827 Disease Relevance 1.33 Pain Relevance 0

General Comments

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