INT254145

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.66
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ppap2a) plasma membrane (Ppap2a)
Anatomy Link Frequency
paw 2
germ cell 1
Ppap2a (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 60 100.00 Very High Very High Very High
intrathecal 30 99.98 Very High Very High Very High
Antinociceptive 132 99.44 Very High Very High Very High
withdrawal 46 98.92 Very High Very High Very High
Inflammation 45 97.72 Very High Very High Very High
Antihyperalgesic 54 97.28 Very High Very High Very High
adenocard 144 96.56 Very High Very High Very High
antiallodynic 48 96.44 Very High Very High Very High
IPN 36 94.72 High High
cytokine 16 88.32 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 21 99.72 Very High Very High Very High
Male Infertility 2 98.62 Very High Very High Very High
INFLAMMATION 60 97.72 Very High Very High Very High
Inflammatory Pain 36 94.72 High High
Apoptosis 15 93.64 High High
Increased Venous Pressure Under Development 26 92.48 High High
Sleep Disorders 12 90.72 High High
Aging 2 90.32 High High
Paralysis 24 90.24 High High
Reprotox - General 1 1 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar azoospermia and reduced germ cell numbers were found in transgenic animals that overexpress lipid phosphate phosphatase, an enzyme that degrades LPA (Yue et al., 2004).
Gene_expression (overexpress) of lipid phosphate phosphatase in germ cell associated with targeted disruption and male infertility
1) Confidence 0.10 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.69 Pain Relevance 0.11
Further positive correlations were seen between MPAP on one hand and IL-8 (?
Gene_expression (seen) of MPAP
2) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2592770 Disease Relevance 0 Pain Relevance 0
The higher MPAP in responders before INO challenge may therefore be explained by their higher ET-1 levels than in nonresponders.
Gene_expression (explained) of MPAP
3) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2592770 Disease Relevance 0.55 Pain Relevance 0.16
Recombinant mPAP has long-lasting antinociceptive properties
Gene_expression (has) of mPAP associated with antinociceptive
4) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0 Pain Relevance 0.35
And, just like hPAP and bPAP mediated antinociception, A1R receptor activation was required for mPAP mediated antinociception.
Gene_expression (antinociception) of mPAP associated with antinociception
5) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.41 Pain Relevance 0.92
A single intraspinal injection of mPAP protein had long-lasting (three day) antinociceptive properties, including antihyperalgesic and antiallodynic effects in the Complete Freund's Adjuvant (CFA) inflammatory pain model.
Gene_expression (injection) of mPAP protein associated with antihyperalgesic, ipn, antiallodynic and antinociceptive
6) Confidence 0.08 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2617779 Disease Relevance 0.16 Pain Relevance 0.69
At the time, we could not perform in vivo gain-of-function studies with mPAP because there were no commercially available sources of secretory mPAP protein.
Neg (no) Gene_expression (sources) of mPAP protein
7) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.18 Pain Relevance 0.49
Intrathecal injection of mPAP produced a significant increase in withdrawal latency to the noxious thermal stimulus (relative to latency on Day 1, pre-injection) in the inflamed paw (Fig. 6A, white open circles).
Gene_expression (injection) of mPAP in paw associated with withdrawal and intrathecal
8) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.37 Pain Relevance 0.78
In addition, mPAP produced a significant increase in withdrawal threshold to the mechanical stimulus (relative to latency on Day 1, pre-injection) only in the inflamed paw (Fig. 6B, white open circles).
Gene_expression (produced) of mPAP in paw associated with withdrawal
9) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.30 Pain Relevance 0.84

General Comments

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