INT254146

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.39
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ppap2a) plasma membrane (Ppap2a)
Ppap2a (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 66 93.24 High High
Lasting pain 15 80.92 Quite High
Spinal cord 12 74.40 Quite High
Neuropathic pain 3 67.44 Quite High
IPN 18 66.60 Quite High
antinociception 30 66.00 Quite High
adenocard 72 64.08 Quite High
Morphine 3 56.92 Quite High
Analgesic 6 56.56 Quite High
agonist 9 54.32 Quite High
Disease Link Frequency Relevance Heat
Pain 24 80.92 Quite High
Neuropathic Pain 6 67.44 Quite High
Inflammatory Pain 18 66.60 Quite High
Targeted Disruption 3 63.08 Quite High
INFLAMMATION 29 50.00 Quite Low
Disease 3 44.80 Quite Low
Nociception 24 38.44 Quite Low
Chemotherapy-induced Neutropenia 1 21.12 Low Low
Increased Venous Pressure Under Development 13 5.00 Very Low Very Low Very Low
Acidosis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PaO2/FiO2 increased from 215 mmHg to 316 mmHg in the responder group (P < 0.05), and the MPAP decreased from 40 mmHg to 30 mmHg (P < 0.05) (Table 1).
Localization (decreased) of MPAP
1) Confidence 0.11 Published 2008 Journal Crit Care Section Body Doc Link PMC2592770 Disease Relevance 0 Pain Relevance 0
Briefly, we infected Hi5 insect cells with high-titer recombinant baculovirus, incubated the cells for 48 hours at 27°C, then harvested and concentrated the supernatant containing secreted mPAP protein.
Localization (secreted) of mPAP protein
2) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0 Pain Relevance 0
Moreover, without pure protein, we could not determine the substrate specificity for secretory mPAP.
Localization (secretory) of mPAP
3) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.26 Pain Relevance 0.52
The mPAP-Tr-(His)6 baculovirus expression clone (encompassing nt 61–1206 from GenBank accession # NM_019807) was generated by PCR amplification, using a full-length expression construct of mPAP (secreted isoform) as template and Phusion polymerase.
Localization (secreted) of mPAP
4) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.13 Pain Relevance 0.49

General Comments

This test has worked.

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