INT254174

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.50
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Irak4) kinase activity (Irak4) cytoplasm (Irak4)
Irak4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 52 94.00 High High
rheumatoid arthritis 70 91.36 High High
cytokine 40 76.36 Quite High
Arthritis 15 67.44 Quite High
chemokine 3 17.68 Low Low
Inflammatory mediators 7 16.24 Low Low
agonist 1 6.96 Low Low
antagonist 7 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 61 94.00 High High
Cancer 8 92.48 High High
Necrosis 8 92.00 High High
Rheumatoid Arthritis 70 91.36 High High
Arthritis 19 67.44 Quite High
Synovitis 2 66.72 Quite High
Targeted Disruption 6 66.68 Quite High
Systemic Lupus Erythematosus 62 65.88 Quite High
Pressure And Volume Under Development 2 63.64 Quite High
Disease 40 57.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Once recruited to the adaptor protein, IRAK4 is activated.
Positive_regulation (activated) of IRAK4
1) Confidence 0.46 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.37 Pain Relevance 0.06
The intracellular signalling cascade of IL-1 is similar to that of the MyD88-dependant TLR cascade discussed previously and involves the induction of IRAK1, IRAK4, MyD88 and transforming growth factor-activated kinase (TAK)1 [26].
Positive_regulation (induction) of IRAK4
2) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 1.13 Pain Relevance 0.46

General Comments

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