INT254177

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.06
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr3) signal transduction (Tlr3) endoplasmic reticulum (Tlr3)
RNA binding (Tlr3) intracellular (Tlr3) cytoplasm (Tlr3)
Anatomy Link Frequency
lung 2
synovium 2
Tlr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 67 100.00 Very High Very High Very High
rheumatoid arthritis 65 97.28 Very High Very High Very High
tolerance 9 92.84 High High
fibrosis 1 74.96 Quite High
cytokine 61 68.56 Quite High
Inflammatory stimuli 2 53.36 Quite High
Inflammatory response 10 23.68 Low Low
Arthritis 15 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 73 100.00 Very High Very High Very High
Cancer 85 98.72 Very High Very High Very High
Rheumatoid Arthritis 65 97.28 Very High Very High Very High
Pneumonia 14 85.44 High High
Injury 11 83.68 Quite High
Metastasis 46 81.36 Quite High
Pulmonary Fibrosis 1 75.76 Quite High
Skin Cancer 8 67.60 Quite High
Bacterial Pneumonia 1 50.40 Quite High
Atypical Pneumonia 2 48.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, this set of experiments yielded results similar to those observed in the first set of experiments in which mechanical ventilation augmented inflammation and lung permeability in the setting of TLR3 activation.
Positive_regulation (augmented) of Positive_regulation (activation) of TLR3 in lung associated with inflammation
1) Confidence 0.41 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.49 Pain Relevance 0.18
This shows that TLR3 is functional in the inflamed synovium and that TLR3 stimulation could potentially result in the production of TNF?
Positive_regulation (result) of Positive_regulation (stimulation) of TLR3 in synovium
2) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.36 Pain Relevance 0.18
In general, stimulation of TLR3, 4, 7, 8, or 9 induces a TH1 or TH17 type of immune response; whereas stimulation of TLR2 induces a TH2, Treg, or TH17 type of immune response [12], [13].
Positive_regulation (induces) of Positive_regulation (stimulation) of TLR3
3) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.21 Pain Relevance 0.21

General Comments

This test has worked.

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